盐酸萘替芬离体透皮吸收的研究  被引量:3

Study on the permeability of naftifine hydrochloride in vitro

在线阅读下载全文

作  者:刘星[1] 乔建忠[1] 耿建兵[1] 袁淑兰[1] 

机构地区:[1]北京军事医学科学院毒物药物研究所

出  处:《中国药学杂志》1999年第6期388-391,共4页Chinese Pharmaceutical Journal

摘  要:目的:研究盐酸萘替芬软膏制剂对离体人皮、豚鼠皮透皮吸收率。方法:采用静态渗透室装置,皮片涂药后不同时间采样,样品中盐酸萘替芬浓度采用高效液相色谱方法测定。结果:盐酸萘替芬经离体人皮、豚鼠皮的渗透率均随着时间的增加而缓慢地增加,36h后,盐酸萘替芬经离体人皮及豚鼠皮的渗透率分别为3.489%和0.726%。结论:盐酸萘替芬软膏人及豚鼠局部皮肤给药后,可能大部分滞留在皮肤表面上,很少透皮吸收。OBJECTIVE: To study the permeability of naftifine hydrochloride ointment through skins of guinea pigs and human beings in vitro. METHODS: A static glass diffusion cell system was used.Samples were collected at different time after the drug was applied.The concentration of naftifine hydrochloride in the samples was measured by HPLC. RESULTS: It showed that the permeability of naftifine hydrochloride through skins of guineap pigs and human beings gradually increased in a slowly manner within the experimental time.The permeability of naftifine hydrochloride through the skins of guinea pigs and human beings at 36hr postapplication were 3.489% and 0.726% respectively. CONCLUSION: Large amount of naftifine hydrochloride may remain in the surface of the skins,and a little may be absorbed through skins of guinea pigs and human beings in vitro after the drug is applied.

关 键 词:盐酸萘替芬 透皮吸收 离体试验 

分 类 号:R978.5[医药卫生—药品] R452[医药卫生—药学]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象