柔红霉素聚氰基丙烯酸正丁酯毫微粒体外释药规律研究  

The in vitro Release Kinetics of Daunorubicin Polybutylcyanoacrylate Nanoparticles

作　　者：彭应旭[1,2] 廖工铁[1,2] 张志荣 

机构地区：[1]华西医科大学药学院药剂学教研室 [2]上海医药工业研究院制剂研究室

出　　处：《华西医科大学学报》1999年第2期168-170,184,共4页Journal of West China University of Medical Sciences

摘　　要：作者用动态膜透析法考察了柔红霉素聚氰基丙烯酸正丁酯毫微粒冻干针剂体外释药规律，并用６种数学模型对释药过程进行拟合，以残差平方和、拟合度、ＡＩＣ等参数为指标，评价了各数学模型的拟合优度。结果表明双指数函数模型能较好地描述毫微粒中柔红霉素的释药规律。The in vitro release kinetics of Daunorubicin Polybutylcyanoacrylate Nanoparticles(DNRPBCANP) was studied by dynamic dialysis system. The concentration of Daunorubicin was determined by spectrophotometry. The result showed the in vitro release kinetics of DNRPBCANP could be well characterized by a biexponential equation. There were two phases in the process of drug release. The initial phase was a fast release phase (the burst effect).The second phase was a slow release phase.

关 键 词：柔红霉素 正丁酯 毫微粒 体外释药 DNR-PBCA-NP 

分 类 号：R978.15[医药卫生—药品] R944.9[医药卫生—药学]