血清中胰岛素样生长因子系统与早期自然流产相关性研究  

The Relationship Between Serum Insulin-like Growth Factor System and Early Spontaneous Abortion

作　　者：陈莉 张艳 张珠兰 

机构地区：[1]广东省深圳市南山区蛇口人民医院检验科,518067 [2]广东省深圳市南山区蛇口人民医院内科,518067 [3]广东省深圳市南山区妇幼保健院妇产科,518052

出　　处：《国际检验医学杂志》2011年第2期169-170,共2页International Journal of Laboratory Medicine

基　　金：广东省深圳市南山区2004年科技立项(项目编号:2004002)

摘　　要：目的探讨血清中胰岛素样生长因子系统(IGFs)与早期自然流产的关系。方法采用酶联免疫法检测48例健康早孕妇女(对照组)和39例早期自然流产患者(流产组)血清中IGF-Ⅰ、IGF-Ⅱ及胰岛素样生长因子结合蛋白-1(IGFBP-1)水平。结果流产组血清中IGF-Ⅰ、IGF-Ⅱ和IGFBP-1浓度依次为(120±13.0)、(115±12.5)和(46±4.2)μg/L,对照组中依次为(186±12.5)、(178±13.0)和(98±12.3)μg/L。两组比较,流产组检测结果低于对照组,差异有统计学意义(P<0.05)。结论血清中IGFs中IGF-Ⅰ,IGF-Ⅱ和IGFBP-1低水平表达与胚胎发育不良及流产发生密切相关。Abstract：Objective To investigate the relationship between insulin like growth factor system and early spontaneous abortion. Methods Serum IGF-Ⅰ ,IGF- Ⅱ and IGFBP 1 were detected by enzyme-linked immunosorbent assay in 48 normal early pregnant women（control group）and 39 patients with early spontaneous abortion（abortion group）. Results The levels of serum IGF-Ⅰ ,IGF-Ⅱ and IGFBP-1 were （120±13.0） ,（115±12.5） and（46±4.2）μg/L respectively in abortions group,and were （186±12.5） ,（178 ± 13.0） and （98±12.3）μg/L respectively in control group. There were significant difference of the levels of serum IGF-Ⅰ ,IGF-Ⅱ and IGFBP -1 between two groups（P〈0.05）. Conclusion The low expression levels of serum IGF-Ⅰ ,IGF- Ⅱ and IGFBP 1,which are included in insulin-like growth factor system,are related： to embryo maldevelopment and abortion.

关 键 词：流产 自然 酶联免疫吸附测定 胰岛素样生长因子-1 胰岛素样生长因子2 胰岛素样生长因子结合蛋白1 

分 类 号：R714.21[医药卫生—妇产科学]