慢性乙型肝炎病毒感染与免疫球蛋白、T淋巴细胞关系的探讨  

Study on the Character of Immunoglobulin and T Cell Subsets in Patients with Chronic Hepatitis B Infection

作　　者：莫红梅[1] 李蕾[1] 

机构地区：[1]新疆维吾尔自治区人民医院检验科,乌鲁木齐830001

出　　处：《国际检验医学杂志》2011年第2期194-195,共2页International Journal of Laboratory Medicine

摘　　要：目的观察慢性乙型肝炎病毒（HBV）感染者不同临床期免疫球蛋白、T淋巴细胞亚群特征，探讨慢性HBV感染病情发展与机体细胞、体液免疫之间关系的变化规律。方法2007～2009年慢性HBV不同临床时期感染者71例，其中，轻、中度慢性乙型肝炎32例，肝炎后肝硬化代偿期21例，肝炎后肝硬化失代偿期18例，并以20例健康人作为健康对照组，检测免疫球蛋白、T淋巴细胞亚群等。结果肝炎后肝硬化代偿期和失代偿期患者外周血中CD3＋T、CD4＋T、CD8＋T淋巴细胞少于慢性乙肝（轻中度）患者和健康对照组，差异具有统计学意义（P〈0．05）；代偿期与失代偿期患者间、慢性乙肝（轻中度）患者与健康对照组间差异无统计学意义（P〉0．05）。慢性乙肝（轻中度）、肝炎后肝硬化代偿期和失代偿期患者7球蛋白均高于健康对照组（P〈0．05），代偿期与失代偿期间患者差异具有统计学意义（P〈0．05）；清蛋白则肝炎后肝硬化代偿期和失代偿期患者显著低于慢性乙肝（轻中度）患者和健康对照组（P〈0．05），代偿期与失代偿期患者间差异具有统计学意义（P〈0．05），慢性乙肝（轻中度）患者与健康对照组间差异无统计学意义（P〉O．05）；肝炎后肝硬化代偿期和失代偿期患者IgG、IgA均显著高于慢性乙肝（轻中度）患者和健康对照组（P〈0．05），代偿期与失代偿期患者间、慢性乙肝（轻中度）患者与健康对照组间差异无统计学意义（P〉0．05）。各组间IgM差异无统计学意义（P〉0．05）。结论慢性HBV感染者随着病情不断进展，细胞、体液免疫功能均不同程度受累。Objective To study the characteristic of immunoglobulin and peripheral blood T ceils subsets in patients with chron- ic hepatitis B. Methods Seventy-one patients with different stages of chronic hepatitis＇B from 2007 to 2009,32 hepatitis B patients with gentle/mild chronic hepatitis B,21 with compensated liver cirrhosis, 18 with decompensated liver cirrhosis and 20 healthy controls were enrolled for observation. The peripheral blood T cells subsets, IgG, IgM, IgA,γ immunoglobulin and albumin were determined. Results The percentage of CD3＋ ,CD4＋ ,CD8＋ T cells in compensated and decompensated liver cirrhosis were lower than in gentle/mild chronic hepatitis B and Control,the difference were significant（P〈0.05）. The differences between gentle/mild chronic hepatitis B and control,compensated and decompensated liver cirrhosis were unsignificant（P〉0.05）. 7 immunogl6bulin in gentle/ mild chronic hepatitis B, compensated and decompensated liver cirrhosis were significantly higher than control（P~ 0. 05）. The difference between gentle/mild chronic hepatitis B and compensated/decompensated liver cirrhosis, compensated and decompensated liver cirrhosis was significant（P〈0.05）. Albumin in compensated and decompensated liver cirrhosis was significantly lower than in gentle/mild chronic hepatitis B and control（P〈0.05）. The di.fference between compensated and decompensated liver cirrhosis was significant（P〈0.05）. IgG,IgA in compensated and decompensated liver cirrhosis were higher than gentle/mild chronic hepatitis B and control（P〈0.05）. No significant difference on IgM in groups（P〉0.05）were observsed. Conclusion Cellular and humoral im- mune function were involved in chronic hepatitis B patients which correlated with disease progress.

关 键 词：肝炎 乙型 肝硬化 T淋巴细胞 免疫球蛋白类 

分 类 号：R512.62[医药卫生—内科学]