GLP-1及其类似物调节β细胞增殖的分子机制  

Molecular Mechanism of Glucagon-like Peptide 1 and Its Analogies Regulating the Proliferation of β Cells

作　　者：肖何[1] 刘建辉[2] 莫志宏[1] 

机构地区：[1]重庆大学化学化工学院,重庆400044 [2]重庆工商大学药物化学与化学生物学研究中心,重庆400067

出　　处：《重庆工商大学学报（自然科学版）》2011年第1期67-69,共3页Journal of Chongqing Technology and Business University:Natural Science Edition

基　　金：重庆市重点基础项目(CSTC;2009BA5069)

摘　　要：胰高血糖素样肽1(Glucagon-like peptide1,GLP-1)是一种L细胞产生的内源性激素,其主要作用是调节胰岛素和胰高血糖素的分泌;越来越多的研究结果表明,GLP-1及其类似物通过激活其受体,在调节胰岛β细胞的增殖和分化、抑制细胞凋亡、促进胰岛素释放、降低血糖以及改善糖耐量等方面都有十分重要的作用;近年来,特别是有关GLP-1及其类似物激活其受体引起的下游细胞信号转导机制有大量的报道,现就GLP-1及其类似物调节β细胞增殖的分子机制及细胞信号转导途径进行综述。Glucagon-like peptide 1 （ GLP-1 ） is a kind of endogenous hormone produced in enteroendocrine L cells of the gut and its particular role is to regulate the secretion of insulin and glucagon. More and more research results show that GLP-1 and its analogies play an important role in the regulation of proliferation and differentiation of β cells,the inhibition of cell apoptosis ,promotion of insulin release,the decrease of blood sugar, the improvement of sugar tolerance and so on through activating its receptor. In recent years, there are a lot of reports on downstream cell signal transform mechanism resulting from the receptor activated by GLP-1 and its analogies. This paper reviews molecular mechanism of GLP-1 and its analogies regulating the proliferation of β cell and its cell signal transform channel.

关 键 词：胰高血糖素样肽1 细胞增殖 反式激活 细胞周期蛋白 

分 类 号：Q279[生物学—细胞生物学]