鲤鱼赤小豆汤对阿霉素肾病大鼠尿蛋白排泄量的影响  

The Effects of Liyu Chixiaodou Tang on Albuminuria in Adriamycin Nephropathy Rats

作　　者：吴慧[1] 于俊生[2] 周晓彬[1] 郭云良[1] 田小剑[1] 刘琳 沈卫[1] 

机构地区：[1]青岛大学医学院,山东青岛266021 [2]青岛大学附属海慈医院,山东青岛266021 [3]洛阳市第一中医院,河南洛阳471002

出　　处：《临床医学工程》2011年第2期165-167,共3页Clinical Medicine & Engineering

基　　金：国家自然科学基金项目(编号:81072754);山东省中医药科技发展计划项目(No.2009-176);青岛大学优秀研究生学位论文培育项目资助

摘　　要：目的探讨鲤鱼赤小豆汤治疗肾病综合征的作用机制。方法成年健康Wistar大鼠50只,经大鼠尾静脉注射阿霉素制备肾病综合征模型,终点法检测实验大鼠阿霉素注射前1W、注射后每3d的12h尿蛋白排泄量,和治疗3W后血清总蛋白、白蛋白水平。结果鲤鱼赤小豆汤组12h尿蛋白排泄量从第9天开始降低,与模型组比较有显著性差异(P<0.01);血清总蛋白和白蛋白水平升高,与模型组比较有显著性差异(P<0.05),鲤鱼赤小豆汤高剂量组显著优于福辛普利组(P<0.05)。结论鲤鱼赤小豆汤高剂量组可以降低肾病综合征模型大鼠尿蛋白排泄量,提高其血清总蛋白和白蛋白水平。Objective To explore the therapeutic mechanism of Liyu Chixiaodou Tang on nephrotic syndrome, Methods The adult health 50 Wistar rats were established nephropathy models by injecting adriamycin to venacaudalis, after one week adaptation and urinary protein excretion detected negative, detected the urinary protein excretion by end-point assay once before injection ADR and every three days after injection ADR. Results The urinary protein excretion in Liyu Chixiaodou Tang group decresed since the 9^ day, existing statistically significant difference compared to the model group （P〈0.01）. Liyu Chixiaodou Tang could increase serum albumin and total protein levels, existing statistically significant difference compared to the model group （P〈0.05）. Conclusion Liyu Chixiaodou Tang can decrease urinary protein and increase serum albumin and total protein levels in adriamycin nephropathy rats.

关 键 词：鲤鱼赤小豆汤 阿霉素肾病 肾病综合征 尿蛋白排泄量 

分 类 号：R277.5[医药卫生—中医学]