美托洛尔缓释片治疗扩张型心肌病临床观察  

Efficacy Observation of Integrated Traditional Chinese and Western Medicine in Treating Acute Pancreatitis of 45 Cases

作　　者：叶福龙[1] 顾卫霞[1] 郑菊[1] 王林全[1] 

机构地区：[1]江苏省吴江市第一人民医院心内科,江苏吴江215200

出　　处：《临床医学工程》2011年第2期258-259,共2页Clinical Medicine & Engineering

摘　　要：目的观察美托洛尔缓释片治疗扩张型心肌病(DCM)的应用方法、药物耐受性及临床疗效。方法 68例扩张型心肌病慢性心衰患者,随机分为治疗组和对照组。对照组常规使用利尿剂、ACEI、强心剂等,治疗组加用美托洛尔缓释片,剂量从12.5mg起始,逐步递增剂量,根据症状、心率、血压,每1～2周剂量翻倍,直至最大耐受量。比较半年(24W)后两组血压及心脏指标变化,评估临床疗效、药物的耐受性、不良反应及靶剂量。结果治疗24W后治疗组与对照组平均心率、最高心率、左室射血分数、心功能的改善程度比较差异均有显著性(P<0.05);最低心率的比较差异无显著性(P>0.05)。结论扩张型心肌病合并心衰患者在常规治疗基础上加用美托洛尔缓释片治疗效果显著,但不同患者对药物的耐受性及用量差异较大,需进行个体化治疗。Objective To observe the methods, tolerance and effect of metoprolol in treating dilated cardiomyopathy. Methods 68 patients were divided randomly into treatment group and control group to compare the related indexes. Results 24 weeks later, the average heart rate, highest heart rate, LVEF and heart function improvement in the treatment group were different more significantly than those in the control group （P〈0.05）, but the lowest heart rate had no significant difference （P 〉0.05）. Conclusion Metoprolol based on regular treatment has significant effects in treating dilated cardiomyopathy complicated with heart failure, but tolerance and doses are different for oatients.

关 键 词：美托洛尔 扩张型心肌病 心力衰竭 

分 类 号：R542.2[医药卫生—心血管疾病] R541.6[医药卫生—内科学]