子宫内膜异位症与肿瘤坏死因子TNFβG252A基因多态性的关系  

TNFβG252A Polymorphisnis in Patients with Endometriosis

作　　者：曾改鸿[1] 黄晓东[1] 

机构地区：[1]广东深圳南方医科大学附属深圳宝安区人民医院,518101

出　　处：《中国社区医师（医学专业）》2011年第4期160-161,共2页

摘　　要：目的:探讨肿瘤坏死因子TNFβG252A基因多态性与子宫内膜异位症的关系。方法:运用聚合酶链反应-限制性片段长度多态性(polymerase chain reaction-restriction fragmentlength polymorphism,PCR-RFLP)技术检测子宫内膜异位症100例及正常100人肿瘤坏死因子TNFβG252A基因多态性。结果:TNFβG252A基因型频率和等位基因频率在两组之间分别为23.0和25.0,58.0和57.0,19.0和18.0,52.5和53.5,47.5和46.5,差异无显著性(P>0.05)。结论:肿瘤坏死因子TNFβG252A基因多态性与子宫内膜异位症无差。Objective：To investigate the relationship between tumor necrosis factor（TNF）polymorphism and endometriosis.Methods：The polymorphism of TNFβG252A was screened by PCR-RELP in 100 patients with endometriosis compared with 100 normal controls.Results：There was no significant difference in the frequencies of TNFβG252A gene between the patients and control group（P0.05）.Conclusion：No evident association was found between TNFβG252A polymorphism and endometriosis.

关 键 词：子宫内膜异位症 肿瘤坏死因子TNFβG252A 基因多态性 

分 类 号：R711.71[医药卫生—妇产科学]