α干扰素的中枢镇痛作用  

THE CENTRAL ANALGESIC EFFECT OF INTERFERON α

作　　者：宋连霞[1] 蒋春雷[1] 路长林[1] 由振东[1] 王云霞[1] 王成海[1] 刘新垣[2] 崔瑞耀[3,3] 

机构地区：[1]第二军医大学神经生物学教研室 [2]中国科学院上海生物化学研究所 [3]青岛医学院病理生理学教研室

出　　处：《中国神经科学杂志》1999年第2期131-133,共3页

基　　金：上海市教委资助;上海市教育发展基金会曙光计划

摘　　要：采用侧脑室给药，以电刺激引起大鼠甩尾反应为指标，测定动物的痛阈。结果显示α干扰素（ＩＦＮα）具有提高大鼠痛阈的作用，其镇痛作用依赖ＩＦＮα剂量，此作用能被抗ＩＦＮα单克隆抗体所阻断。纳洛酮、μ阿片受体特异性拮抗剂β－ＦＮＡ能够阻断ＩＦＮα的镇痛作用，而δ和κ阿片受体特异性拮抗剂则没有这一作用，表明ＩＦＮα的中枢镇痛作用由μ阿片受体所介导。With using the tail flick induced by electro stimulation as pain marker,it was found that pain threshold was increased significantly after injecting interferon α (IFNα) into the lateral cerebral ventricle of rats.This effect was dose dependent and abolished by monoclonal antibody to IFNα.Naloxone and specific antagonist of μ(not δ and κ)opiate receptor could inhibit the analgesic effect of IFNα,suggesting that the analgesic effect of IFNα be mediated by μ opiate receptor.

关 键 词：Α干扰素 痛阈 阿片受体 侧脑室 镇痛 

分 类 号：R979.5[医药卫生—药品] R338.3[医药卫生—药学]