父亲HBV携带与婴儿HBV感染的关系  

A study on hepatitis B virus transmission from father to infant

作　　者：卢银平[1] 曹伟[2] 洪梅[2] 祝建芳[1] 刘朝[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院病毒研究室,湖北武汉430022 [2]华中科技大学同济医学院附属协和医院妇产科

出　　处：《中国妇幼保健》2011年第2期220-221,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨父亲乙型肝炎病毒(HBV)感染携带对婴儿HBV感染的影响。方法:收集88例该院妇产科出生婴儿脐血及其父亲血标本,经筛查已确认母亲无HBV感染,父亲为HBV感染携带者。应用酶联免疫吸附试验(ELISA)检测父亲HBV血清学标志物,荧光定量PCR(FQ-PCR)检测父亲和婴儿血清中HBV DNA含量。分析父亲HBV血清学标志物不同模式和HBV DNA含量对婴儿HBV感染的影响。结果:88例父亲为HBV感染携带者的婴儿共检出24例阳性,父婴传播率为27.3%。父亲不同血清学感染模式影响了婴儿HBV感染率,其中"大三阳"模式组的父婴传播率显著高于"小三阳"模式组(2χ=6.468,P<0.05)和其他模式组(2χ=5.869,P(0.05)。同时,父亲血清HBV病毒载量也影响了婴儿HBV感染率,当父亲外周血中病毒载量≥1×106 copies/ml时,HBV父婴传播率显著高于其他低病毒载量组(2χ=6.680、5.397、6.423、4.474,P值均(0.05)。结论:父亲血清学"大三阳"感染模式是HBV父婴传播的高危影响因素;父亲高病毒载量增加了HBV父婴传播的危险性。Objective： To investigate the relationship between hepatitis B virus （HBV） paternal -infant transmission and father＇s status of HBV chronic infection. Methods ： A total of 88 cord blood samples from infants with father HBV carriers and mother no HBV infection were collected. ELISA was used to detect HBV serologic markers, and HBV loads in sera were determined by fluorescence quantitative PCR （FQ- PCR） . Results： HBV paternal -infant transmission rate was 27.3% in 88 eases of infants （24/88） . The paternal- infant transmission rate in ＂ HBsAg/HBeAg/HBeAb＂ group was significantly higher than that of ＂ HBsAg/HBeAb/HBeAb＂ group （Х^2 = 6. 468, P 〈 0.05 ） and the other group （Х^2= 5. 869, P 〈 0. 05 ） . Further more, the positive rate of HBV infection of infants in father high HBV loads group was also significantly higher than that of father low HBV loads group （ P 〈 0. 05 ） . Conclusion ： The paternal - infant transmission rate is influenced by father serum HBV loads. Higher serum HBV loads and ＂ HBsAg/HBeAg/HBeAb＂ serologic markers model may increase risk of paterua - infant transmission.

关 键 词：乙型肝炎病毒 父婴传播 荧光定量PCR 

分 类 号：R725.1[医药卫生—儿科]