氟伐他汀对急性冠脉综合征患者炎性因子水平和心血管事件发生率的影响  

Effects of Fluvastatin on Levels of Inflammation Factor and Cardiovascular Events in Patients with Acute Coronary Syndromes

作　　者：郑颖[1] 江华[1] 孙凯[1] 李智山[1] 刘文卫[1] 刘永胜[1] 李艳[2] 

机构地区：[1]湖北省襄阳市中心医院,邮政编码襄阳441021 [2]武汉大学人民医院

出　　处：《微循环学杂志》2011年第1期44-46,I0002,共4页Chinese Journal of Microcirculation

摘　　要：目的:观察氟伐他汀对急性冠脉综合征(ACS)患者血清白细胞介素-18(IL-18)、肿瘤坏死因子-α(TNF-α)和超敏C-反应蛋白(hs-CRP)水平的影响,探讨其对心血管事件发生率的影响。方法:134例ACS患者被随机分成氟伐他汀干预组和常规治疗组,同时设置健康对照组;检测ACS两组治疗前、治疗后2周IL-18、TNF-α、hs-CRP水平变化,观察心血管事件发生情况。结果:ACS组治疗前与对照组比较血清IL-18、TNF-α及hs-CRP水平明显升高,治疗后常规治疗组与氟伐他汀干预组IL-18、TNF-α及hs-CRP均较治疗前降低(P<0.05),氟伐他汀干预组降低更明显(P<0.01);且随访期间发生死亡、心衰、心绞痛、心肌梗死也明显少于常规治疗组(P<0.05)。结论:氟伐他汀可以降低ACS患者血清炎症因子水平,抑制炎症反应,从而减少心血管事件的发生。Objective:To investigate the effects of fluvastatin on levels of interleukin-18(IL-18),tumor necrosis factor-α(TNF-α),high-sensitivity CRP(hs-CRP) and cardiovascular events in patients with acute coronary syndromes.Method:The study groups included 134 cases of acute coronary syndrome( ACS) patients,which randomly were divided into routine drugs and addititonal fluvastatin cases,and normal controls.Levels of IL-18,TNF-α,hs-CRP and cardiovascular events were measured before and after treatment.Results:IL-18,TNF-α and hs-CRP levels were significantly higher in patients with ACS before treatment than normal control group.Levels of IL-18,TNF-α and hs-CRP were decreased after treatment of fluvastatin and routine,but the group treated with fluvastatin decreased higher than the routine treat group,during observation the composite of cardiac death,recurrence of unstable angina,re-infarction reduced also.Conclusion:These results showed that inflammation was existent in ACS,fluvastatin could significantly depress inflammation and reduce cardiovascular events.

关 键 词：急性冠脉综合征 氟伐他汀 白介素-18 肿瘤坏死因子-α 超敏C反应蛋白 心血管事件 

分 类 号：R541.4[医药卫生—心血管疾病] R453.9[医药卫生—内科学]