2-(2-(6-氯己氧基)乙氧基)乙氨的合成  

Preparation of 2-(2-((6-chlorohexyl)oxy)ethoxy) ethanamine

作　　者：林润锋[1,2] 张珩[2] 钟武[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850 [2]武汉工程大学绿色化工过程省部共建教育部重点实验室,湖北武汉430073

出　　处：《化学试剂》2011年第2期161-163,共3页Chemical Reagents

基　　金：国家自然科学基金资助项目(30701042)

摘　　要：2-(2-氨基乙氧基)乙醇溶于乙醇,用叔丁氧羰基酸酐(Boc2O)进行氨基保护得N-叔丁氧羰基-2-(2-氨基乙氧基)乙醇,与1-氯-6-溴己烷在正己烷及50%NaOH和四丁基溴化铵作用下缩合,得N-叔丁氧羰基-2-(2-(6-氯己氧基)乙氧基)乙氨,最后在二氯甲烷及三氟乙酸混合液中脱保护,得标题化合物,总收率11.4%。Firstly,2-(2-aminoethoxy)ethanol reacted with di-tert-butyl dicarbonate(Boc2O) in ethanol solution for protecting the amino group.Then the condensation of the thereby obtained tert-butyl-(2-(2-hydroxy) ethyl) carbamate with 1-bromo-6-chlorohexane was carried out in the presence of NaOH(50%) and tetrabutylammonium bromide to form tert-butyl(2-(2-(6-chlorohexy)oxy)ethyl)carbamate.Finally,tert-butyl(2-(2-(6-chlorohexy)oxy)ethyl)carbamate was subjected to de-protection in a mixture of dichloromethane and trifluoroacetic acid to yield(2-(2-(6-chlorohexy)oxy)ethyl)carbamate,with an overall yield reaching 11.4%.

关 键 词：HALO Tag蛋白标记 2-(2-(6-氯己氧基)乙氧基)乙氨 WILLIAMSON 反应 

分 类 号：O622.6[理学—有机化学]