一级直链溴化物的一锅法羟醛缩合反应  

One-pot aldol condensation of primary straight-chain bromides

作　　者：邵春雁[1] 邱太源 孙小强[1] 

机构地区：[1]江苏工业学院化学化工学院,江苏常州213164 [2]常州元朔化工科技有限公司,江苏常州213164

出　　处：《化学试剂》2011年第2期187-189,共3页Chemical Reagents

基　　金：常州市科技型中小企业技术创新资金计划资助项目(CN20090017)

摘　　要：研究了3个一级直链溴化物的一锅法羟醛缩合反应。分别以l-溴己烷、1-溴庚烷、l-溴辛烷为原料，用吡啶氮氧化物氧化，无水碳酸钠作为碱，甲苯作为溶剂，一锅法反应得到羟醛缩合反应产物，产率48．0％～5,4．9％。产品结构经1^HNMR、MS、IR进行表征。This article investigated one-pot aldol condensation reactions involving primary straight-chain bromoalkanes.Three products were synthesized using 1-bromohexane,1-bromoheptane and 1-bromoctane as starting materials,pyridine-N-oxide as the oxidizer,sodium carbonate as the base,and toluene as the solvent.The foregoing one-pot synthesis reactions gave product yields in the range of 48.0% to 54.9%.The structures of the synthesized aldols were verified by 1HNMR,MS and IR spectroscopy.

关 键 词：溴化物 一锅法 羟醛缩合 

分 类 号：O622.4[理学—有机化学]