武汉地区新生儿感染鲍氏不动杆菌耐药性监测与分析  

Drug resistance surveillance of acinetobacter baumanii isolated from neonatus in Wuhan

作　　者：鲍连生[1] 虞涛[1] 黄永国[1] 刘芳[1] 杜桃枝[1] 余星[1] 吴? 

机构地区：[1]武汉市妇女儿童医疗保健中心,湖北武汉430016

出　　处：《中华医院感染学杂志》2011年第4期798-799,共2页Chinese Journal of Nosocomiology

基　　金：武汉市卫生局科研基金(2008)

摘　　要：目的了解武汉地区新生儿感染鲍氏不动杆菌(ABA)对抗菌药物的耐药性变迁。方法采用K-B法进行药物敏感试验,按CLSI 2008年版判断结果,使用χ2检验分析耐药性的变化。结果新生儿感染分离ABA 458株,分离率呈逐年上升趋势;2007-2009年分离ABA对哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、头孢吡肟、头孢他啶、亚胺培南、美罗培南的耐药率均呈逐年显著上升,差异有统计学意义(P<0.05)。结论武汉地区新生儿分离ABA耐药率明显低于成人分离株,但其耐药性呈逐年上升趋势,提示加强医院感染管理,合理使用抗菌药物及耐药菌监测的重要性。OBJECTIVE To understand the change of drug resistance of Acinetobacter baumanii isolated from neonatus in Wuhan area. METHODS Antimicrobial susceptibility test was performed by Kirby-Bauer method. And the results of antimicrobial susceptibility test were judged according to CLSI 2008. The change of antimierobial resistance was analyzed by χ^2 test. RESULTS A total of 458 strains of ABA were isolated. There was a rising tendency in the isolation rate year by year. The results of the statistics showed that the drug resistant rates of ABA isolated from 2007 to 2009 to piperacillin/tazobactam, cefoperazone/sulbaetam, cefepime, ceftazidime, imipenem and meropenem were significantly increased year by year. The difference was statistically significant （P〈0.05）. CONCLUSION The antimicrobial resistance of ABA isolated from neonatus in Wuhan area is significantly lower than that from adults. But the antimicrobial resistance is on the rise year by year. So it is important to strenthen the administration of nosocomial infections, rationally apply the antibiotics and monitor the drug resistant isolates.

关 键 词：武汉地区 鲍氏不动杆菌 新生儿 医院感染 耐药性 

分 类 号：R378[医药卫生—病原生物学]