皮肤溃疡愈合规律中肌平皮长及皮长肌平的观察  

Observation of the Law of Skin Ulcer Healing “Proper Growth of Granulation Tissue Promotes Epithelium Growth and the Epithelium Growth Regulates the Growth of Granulation Tissue”

作　　者：王建平[1] 周成宝[1] 苏明[1] 李兰青[1] 梅妍[1] 耿华[1] 李竞[1] 

机构地区：[1]天津市中医药研究院疮疡所

出　　处：《中国中西医结合外科杂志》1999年第4期219-222,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的：观察创面和皮缘的角度对愈合的影响。方法：采取手术造模，使皮肤创缘与创面呈９０°，称“直切组”。皮肤创缘与创面呈１３５°，称“斜切组”。分别观察术后３、５、７、１４、２１、２８ｄ病理变化。结果：斜切组，在创伤早期毛细血管数量丰富（Ｐ＜０．０５）；纤维母细胞明显丰富（Ｐ＜０．０１）；皮缘上皮增生出现早，爬行生长速度快；在愈合全过程中炎性细胞计数显示炎性反应轻；愈合明显快（Ｐ＜０．０１）。结论：创缘与创面角度越大，越利于炎性渗出物的引流，保留较多的基底层细胞对于伤口收缩及肉芽组织中毛细血管、纤维母细胞生长均有促进作用，有利于伤口的愈合，符合李竞提出的“肌（肉芽）平皮（上皮）长、皮长肌平”的皮肤溃疡愈合规律。Objective:To observe the influence of the angle between traumatic surface and edge to healing.Methods:Traumatic models were made by operation.The angle of vertical incision group is 90 degrees with traumatic surface,the oblique incision group is 135 degrees.The pathologic changes were observed on the 3rd,5th,7th,14th,21st,28th days respectively after operation.Results:In the oblique incision group capillaries (P <0 04)and fibroblasts (P <0 05)were much more than those in the other group in the initial period.Epithelial cells on the traumatic edge were hyperplastic earlier,and the speed of crawling growth was rapid.Only a little inflammatory reaction was shown,and the healing rate much more quickly than in the vertical incision group (P <0 01).Conclusion:

关 键 词：皮肤溃疡 愈合规律 肌平皮长 皮长肌平 

分 类 号：R632.1[医药卫生—外科学]