聚-4-羟基丁酸的微生物合成及医学应用  

MICROBIAL SYNTHESIS AND MEDICAL APPLICATION OF POLY-4-HYDROXYBUTYRATE

作　　者：张岩峰[1] 田立[2] 宋水山[1] 

机构地区：[1]河北省科学院生物研究所,石家庄050051 [2]河北医科大学第一附属医院,石家庄050031

出　　处：《工程塑料应用》2011年第1期48-52,共5页Engineering Plastics Application

基　　金：国家自然科学基金项目(30970030)

摘　　要：聚-4-羟基丁酸[P(4HB)]是由微生物在非平衡生长条件下胞内积累的高分子聚酯,具有高柔韧性、生物相容性、生物可降解性、热塑性等特点。P(4HB)作为可吸收材料可用于制备医用可植入器件,如制备补片、心脏瓣膜和人造血管等治疗心血管疾病;制备手术缝合线;制备软组织修复材料;用于药物缓释体系。研究表明,生物发酵合成的P(4HB)是一种优良的医用生物材料。Poly-4-hydroxybutyrate [P（4HB） ] was synthesized as a polyester intracellularly by microorganisms under unbalanced growth conditions. It was characterized by flexibility, biocompatibility, biodegradability, thermoplastic, etc. As a absorbable material, P（4HB） could be used to prepare the implantable medical devices, such as patch, heart valves, vascular grafts for cardiovascular disease etc. , suture for surgical operation, agents for soft tissue repair and drug release. P（4HB） from microbial production was an excellent material for biomedical application.

关 键 词：聚-4-羟基丁酸微生物合成组织工程 

分 类 号：TQ324.9[化学工程—合成树脂塑料工业]