西洋参二醇组皂甙对鼠心异位移植后心肌缺血再灌注损伤的保护作用  

Protective Effect of Panaxadiol Quinqueloium Saponins on Ischemic Myocadial Reperfusion Injury after Heterotopic Heart Transplantation in Rats

作　　者：孙承军[1,2] 屈大望 段淑梅[1,2] 王长利 

机构地区：[1]天津医科大学附属肿瘤医院 [2]山东胜利油田油建一公司卫生院

出　　处：《中国中西医结合外科杂志》1999年第4期262-264,共3页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的：了解西洋参二醇组皂甙（ＰＱＳ）作为心脏停搏液的添加剂对鼠心异位移植后心肌缺血再灌注损伤的保护作用。方法：以鼠心腹部异位移植模型为研究手段，以心肌细胞内钙含量及受体鼠血清中ＣＫ、ＣＫＭＢ活力为观察指标，以Ｓｔ．ＴｈｏｍａｓⅡ号心脏停搏液为对照组。结果：ＰＱＳ可降低移植心脏心肌细胞内钙含量，降低受体鼠血清中ＣＫ、ＣＫＭＢ活力。结论：ＰＱＳ抗缺血再灌注损伤的机理为钙拮抗剂样作用。Objective:To understand the protective effect of panaxadial quinqueloium saponins(PQS)on the ischemic myocardial reperfusion injury as an additive agent in the cardioplegic solution after the heterotopic heart transplantation in rats.Methods:The heterotopic heart transplantation model of rats was used,the calcium content and activity of CK,CK-MB in the recepient rats were taken as the indices of observation.Results:PQS could reduce the calcium content of the transplanted heart in the myocardial cells and activity of CK,CK-MB in the recepient rats.Conclusion:The mechanism of PQS antagonizing ischemic reperfusion injury was the effect like calcium antagonist.

关 键 词：西洋参 二醇组皂甙 缺血 再灌注损伤 心异位移植 

分 类 号：R259.422[医药卫生—中西医结合] R654.205[医药卫生—中医内科学]