阿卡波糖片的亲水色谱法测定  

Determination of Acarbose Tablets by Hydrophilic-interaction Chromatography

作　　者：谢赞[1] 杜旭召[1] 何丽娟[1] 陈玉洁[1] 史颖[1] 

机构地区：[1]石药集团中奇制药技术(石家庄)有限公司,河北石家庄050051

出　　处：《中国医药工业杂志》2011年第2期127-129,共3页Chinese Journal of Pharmaceuticals

基　　金：国家科技重大专项课题(2008ZX09401-004)

摘　　要：建立了亲水色谱法测定阿卡波糖片的含量及其有关物质。采用Phenomenex氨基柱,以6 mmol/L磷酸二氢钾缓冲液(pH 6.8)-乙腈(28:72)为流动相,检测波长210 nm。阿卡波糖在4～20 mg/ml浓度范围内线性关系良好。平均回收率为99.2%,RSD为0.7%。A hydrophilic-interaction chromatography method was established for the determination of acarbose tablets and its related substances.A Phenomenex NH_2 column was used with the mobile phase of 6 mmol/L potassium dihydrogen phosphate buffer（pH 6.8） -acetonitrile（28：72）,at the detection wavelength of 210 nm.The calibration curve was linear in the concentration range of 4-20 mg/ml.The average recovery was 99.2%with RSD of 0.7%.

关 键 词：阿卡波糖 片剂 亲水色谱 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.73[化学工程—制药化工]