含肟酯类姜黄素衍生物的合成及其抗病毒活性  

Synthesis of Oxime-esters of Curcumin Derivatives and Their Anti-CMV Activities

作　　者：仇秋娟[1] 薛伟[1] 卢平[1] 王贞超[1] 魏学[1] 

机构地区：[1]贵州大学精细化工研究开发中心绿色农药与农业生物工程国家重点实验室培育基地教育部绿色农药与生物工程重点实验室,贵州贵阳550025

出　　处：《合成化学》2011年第1期36-40,77,共6页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(20662004);贵州大学研究生创新基金资助项目(2010022)

摘　　要：采用生物活性因子拼接法将肟酯引入单羰基姜黄素衍生物1,5-二取代芳基-1,4-戊二烯-3-酮中,合成了11个新型不对称1,5-二取代-1,4-戊二烯-3-酮肟酯类姜黄素衍生物,其结构经1H NMR,IR和元素分析表征。初步生物活性测试结果表明,部分化合物具有一定的抗黄瓜花叶病毒(CMV)活性。Curcumin was modified by active functional group oxime ester with biologically active factor splicing of 1,5-diphenyl-1,4-pentadien-3-one compound.Eleven novel oxime-esters of curcumin derivatives were synthesized.The structures were characterized by 1H NMR,IR and element analysis.The preliminary bioassay showed that some of them exhibited a certain inhibitory activity of anti-CMV.

关 键 词：姜黄素 肟酯 合成 抗病毒活性 

分 类 号：O625.1[理学—有机化学]