新型C_2轴对称吡啶羧酸酯手性多齿配体的合成  

Synthesis of Novel Chiral Polydentate Ligands of C_2-symmetric Pyridinecarboxylic Esters

作　　者：姜艳[1] 卜云飞[1] 李正义[1] 孙小强[1] 

机构地区：[1]常州大学江苏省精细石油化工重点实验室,江苏常州213164

出　　处：《合成化学》2011年第1期81-84,共4页Chinese Journal of Synthetic Chemistry

基　　金：江苏省精细石油化工重点实验室开放课题资助项目(ICF0503)

摘　　要：以L-(+)-酒石酸和吡啶甲酸为原料,经酯化,缩合、还原、DCC-DMAP催化酯化等反应合成了3个新型手性多齿配体——(4R,5R)-1,3-二氧戊环-2-苯基-4,5-二吡啶羧酸酯(5a～5c),其结构经1H NMR,13C NMR,IR和MS表征,并通过高斯软件HF/6-31G模拟了5a可能的分子结构。Three novel chiral polydentate ligands,（4R,5R）-1,3-dioxolane-4,5-bis-pyridinecarboxylic esters（5a～5c）,were synthesized from L-（＋）-tartaric acid and pyridinecarboxylic acids by a four-step reaction of esterification,condensation,reduction and DCC-DMAP catalytic esterification.The structures were characterized by 1H NMR,13C NMR,IR and MS.The probable molecular structure of 5a was imitated by molecular simulation software Gaussian HF/6-31G.

关 键 词：手性多齿配体 吡啶羧酸酯 吡啶甲酸 合成 

分 类 号：O621.3[理学—有机化学]