中医“医未病”的现代病理学基础研究  

Study on the Modern Pathological Basis of the Prevention Early Treatment of Disease in TCM

作　　者：尹光耀[1,2] 刘敏丰[1,2] 沈小静[1,2] 陈一[1,2] 张武宁[1,2] 

机构地区：[1]无锡市中西医结合医院 [2]无锡市第三人民医院,江苏无锡214041

出　　处：《辽宁中医杂志》2011年第2期218-221,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:探索中医"有证无病"、"有证有病"和"无证有病"的现代病理学基础。方法:取225例脾虚证患者胃黏膜和42例平素无临床症状的志愿献血者的胃黏膜,应用光学显微镜、扫描电镜、组织化学染色和即用型非生物素免疫组织化学ElivisionTM Plus方法,检测胃黏膜组织切片P53、Ki67、CerbB2、P21ras表达,进行组织病理学、胃黏膜超微结构方法分析;结果:脾气虚证和脾阳虚证胃黏膜既可有器质性病变存在(G型,发生在CSG、CAG基础上-有病有证);也可无器质性病变存在(F型,多为功能性消化不良-无病有证);脾阴虚证和脾虚气滞证均发生在CSG、CAG和CA基础上,且CSG、CAG和CA的炎症细胞浸润黏膜层程度、固有膜腺体减少程度和IMⅡb发生率,P53,Ki67,CerbB2,Ras表达发生率和胃黏膜灶性萎缩性胃炎、灶性肠化生、微小溃疡与幽门螺杆菌("背景病变")也较G脾气虚证、G脾阳虚证的CSG、CAG为重,P<0.05～0.01。结论:有证无病、有病无证和有证有病发生在胃黏膜病理学量变基础上。Objective：To Explore the modern pathological basis of symptoms without disease,disease without symptoms and disease with symptoms in TCM.Methods：By means of optical microscope,SEM and histochemical staining,we conducted histopathological analysis of gastric mucosa of 225 spleen deficiency patients,and that of 42 voluntary blood donors usually devoid of clinical symptoms.Results：The gastric mucosa of patients with SQD and SyangD could either be affectted by organic lesion（type G,occuring on the basis of CSG,CAG,CA-disease with symptoms） or unaffected（type F,chiefly belonging to functional indigestion-nondisease with symptoms）;SyinD and SDQS both occurred on the basis of CSG,CAG and CA-disease with symptoms;and the degree of mucosa inflammatory cells infiltration,the degree of decrease in glands propria,and the incidence of IMⅡb,and the rate of P53,Ki67,CerbB2 andRas’s expression,and the incidence of focal atrophic gastritis and focal IM and icro-ulcer and Helicobacter Pylon（＂background lesion＂） in CSG,CAG were more serious than those of G-SQD,G-SyangD,P〈0.05～0.01.Conclusion：Disease with symptoms,disease without symptoms,non disease with symptoms occur on the pathological basis of the quantitative changes of gastric mucosa.

关 键 词：有证无病 有病无证 有证有病 P53 KI67 CERBB2 RAS表达 现代病理学基础 

分 类 号：R2-03[医药卫生—中医学]