双黄连注射剂不良反应及其影响因素回顾性调查  

Retrospective investigation of ADR caused by shuanghuanglian injection and influential factors

作　　者：程光文[1] 曾婧[1] 毛宗福[2] 韩定芬[2] 李汝霖[2] 

机构地区：[1]武汉科技大学医学院,430065 [2]武汉大学公共卫生学院,430071

出　　处：《重庆医学》2011年第4期362-363,365,共3页Chongqing medicine

基　　金：湖北省教育厅科研基金重点项目(D200611007)

摘　　要：目的了解双黄连注射剂在临床应用中的不良反应的发生状况,以及不良反应的类型和特点,为双黄连注射剂在临床中的安全性评价和指导临床合理用药提供科学依据。方法以整群抽样方法,随机抽取静脉滴注双黄连注射剂患者的完整住院病历资料,对双黄连注射剂不良反应的发生及其影响因素进行回顾性分析。结果不良反应发生率为2.56%,主要的不良反应为过敏反应,不良反应发生率男性高于女性(P<0.05)。不良反应与用药时间、用药剂量和合并用药均有关(P<0.05)。结论双黄连注射剂也可以引起不良反应,临床上应注意合理用药,采取对策减少不良反应的发生,保障用药安全。Objective To investigate the incidence rates,types and influential factors of adverse drug reactions（ADR） of shuanghuanglian injection,to provided the scientific evidence for the safety evaluation of shuanghuanglian injection and guide application in clinical.Methods The patients used shuanghuanglian injection were investigated by cluster sampling,and the ADR of shuanghuanglian injection and influential factors were analyzed by case retrospective study.Results The incidence rate of ADR was 2.56%,the main ADR of shuanghuanglian injection was allergic reactions.The ADR rate in male was significantly higher than that in female（P0.05）.The medication days,medication dosage and drug combination had significant influence（P0.05）.Conclusion Medical staff should pay attention to rational medication in clinical to decrease the incidence rate of ADR and to improve security of use of drug.

关 键 词：双黄连注射剂 数据收集 不良反应 影响因素 

分 类 号：R285[医药卫生—中药学]