系列樟脑型β-二酮化合物的合成  

Synthesis of a Series of Camphor-type β-dione Compounds

作　　者：谢运[1] 骆开均[1] 蒋世平[1] 徐玲玲[1] 

机构地区：[1]四川师范大学化学与材料科学学院,四川成都610066

出　　处：《四川师范大学学报（自然科学版）》2011年第1期91-94,共4页Journal of Sichuan Normal University（Natural Science）

基　　金：国家自然科学基金(21072141);四川省教育厅自然科学重点基金(08ZA040)资助项目

摘　　要：樟脑由于具有较大的空间位阻,其α位的亚甲基较直链α位碳难活化.从D(+)-樟脑出发,采用高沸点的乙二醇二乙醚做溶剂,氢化钠作碱催化剂,合成了3-苯甲酰基樟脑,3-乙酰基樟脑和3-三氟乙酰基樟脑等系列樟脑型β-二羰基化合物,产率为30%～58.3%.目标产物用1H NMR,质谱(MS)来表征.并讨论了溶剂,碱催化剂以及提纯方法对反应的影响.The α-methylene of camphor is very hard to be activated because of the steric hindrance.In this paper,a series of camphor-type β-dione compounds are synthesized by using D（＋）-camphor as starting material,ethylene glycol diethyl ether as solvent,and sodium hydride as a basic catalyst.The target compounds are obtained in a yield of 30%~58.3% and are characterized by 1H NMR and MS.The influences of solvent,basic catalyst and purification method on the reaction are also discussed.

关 键 词：D(+)-樟脑 合成 樟脑型β-二酮 

分 类 号：O626.4[理学—有机化学]