积雪草总苷对高脂血症小鼠的干预作用  

Intervention effects of Gotu Kola P.E.on hyperlipemia mice

作　　者：陆海鹏[1] 李彬 马维 

机构地区：[1]广西民族医院,南宁530001 [2]广西昌洲天然产物开发有限公司,南宁530023

出　　处：《重庆医学》2011年第5期427-429,共3页Chongqing medicine

摘　　要：目的观察积雪草总苷对高脂乳剂诱导的高脂血症小鼠的血脂及肝脏调节作用。方法以高脂肪乳剂连续灌胃制作小鼠高脂血症模型,给予不同剂量的积雪草总苷予以干预,以复方蛋氨酸胆碱为阳性对照组,1周后检测小鼠血清以及肝组织匀浆TC、TG、HDL-C、ALT、AST含量以及小鼠肝脏组织病理变化,以评价积雪草总苷干预效果。结果积雪草总苷能降低高脂血症小鼠血清以及肝脏组织匀浆中TC、TG含量(P<0.05),同时降低血清LDL-C、ALT、AST含量(P<0.05)。结论积雪草总苷能够起到调节脂质代谢、保护肝脏的作用,值得深入研究以及开发利用。Objective To observe the intervention effects of Gotu Kola P.E.on hyperlipemia and fatty liver mice which were caused by high-fat diet.Methods The hyperlipemia and fatty liver mice were molded by continuously feeding high-fat diet,comparison with DBGT.TC,TG,HDL-C,ALT,AST and liver organization pathology were examined.Results Gotu Kola P.E.could obviously reduce TC,TG levels in liver,as well as LDL-C level in serum and ALT,AST activities in serum.Conclusion Gotu Kola P.E.could obviously improve the hyperlipemia and alleviate the fatty denaturation of mice.It is worthy of further research.

关 键 词：积雪草 高脂血症 动物 实验 

分 类 号：R285.5[医药卫生—中药学]