甘草汤对大鼠心肌缺血再灌注损伤的影响  

The Effects of Gancao Decoction on Myocardial Ischemia Reperfusion Injury in Rats

作　　者：李美平[1] 何承敏[1] 胡继鹰[1] 尤行宏[1] 胡平[1] 

机构地区：[1]湖北中医药大学,湖北武汉430065

出　　处：《湖北中医学院学报》2011年第1期9-11,共3页Journal of Hubei College of Traditional Chinese Medicine

基　　金：湖北省教育厅重点课题(2001A04012)

摘　　要：目的观察甘草汤对大鼠心肌缺血再灌注损伤的影响,并探讨其机制。方法采用结扎左冠状动脉前降支15min,再灌注30min后制备大鼠心肌缺血再灌注模型,以再灌性心律失常、血清NO含量和心肌Ca2+-Mg2+-ATPase活性为观察指标。结果甘草汤组动物再灌注心律失常发生率低于模型组(P<0.01),血清NO含量显著提高(P<0.01),Ca2+-Mg2+-ATPase活性明显增强(P<0.01)。与心律平组比较,甘草汤组各项指标无显著性差异(P>0.05)。结论甘草汤对心肌缺血再灌性心律失常具有保护作用,其机制可能与提高NO含量,减轻钙超载有关。Objective To observe The effects of Gancao decoction on myocardial ischemia-reperfusion injury in rats and its mechanism.Methods Myocardial ischemia-reperfusion injury model was induced by ligation of the left anterior descending coronary artery 15min followed by 30min reperfusion.All the indexes（reperfusion arrhythmia,serum NO and myocardial Ca2＋-Mg2＋-ATPase activity） were measured.Results Compared with model group,the incidence of reperfusion arrhythmias of Gancao decoction group was obviously decreased（P0.01）,serum NO were significantly elevated（P0.01）,Ca2＋-Mg2＋-ATPase activity was markedly increased（P0.01）.Compared with propafenone group,all the indexes of Gancao decoction showed no significant differences（P0.05）.Conclusions Gancao decoction is protective to heart against ischemia-reperfusion arrhythmia,of which the mechanism may be related to increasing NO content and reducing the Ca2＋ overload.

关 键 词：甘草汤 缺血再灌注损伤 一氧化氮 ATP酶 

分 类 号：R285.5[医药卫生—中药学]