116株鲍曼不动杆菌的感染分布及耐药性分析  

Analysis on Infection Distribution and Drug Resistance of 116 Strains of Acinetobacter Baumannii

作　　者：林胜兰[1] 李静[1] 王龙飞 

机构地区：[1]西南大学资源环境学院,重庆北碚400716 [2]四川省南充市中心医院药剂科,四川南充637000

出　　处：《中国药业》2011年第4期22-23,共2页China Pharmaceuticals

摘　　要：目的调查南充市中心医院116株鲍曼不动杆菌的感染分布与耐药情况,为医院临床诊治提供参考。方法对2009年2月至2010年2月住院患者送检标本分离的116株鲍曼不动杆菌的感染分布与耐药情况进行回顾性分析,采用法国生物梅里埃公司生产的VITEK-32全自动微生物鉴定及药敏系统对收集的样本进行菌株鉴定和药物敏感性试验。结果鲍曼不动杆菌最常出现在痰标本中(占86.10%),其次是创口分泌物;主要分布科室为ICU病房,其次是神外科和呼吸科;对头孢西丁耐药率最高(为95.60%),对亚胺培南的耐药率最低(为3.60%),对含酶抑制剂的替卡西林克拉维酸、头孢哌酮舒巴坦、阿莫西林克拉维酸钾的耐药率分别为23.60%,32.40%和34.70%,对其他14种所试抗菌药物的耐药率均较高,多重耐药性明显。结论鲍曼不动杆菌主要引起下呼吸道感染,其敏感抗生素谱窄,亚胺培南等碳青霉烯类抗生素可作为首选治疗药物;医院应加强对该菌的监测,并根据药物敏感性报告合理选用抗菌药物以提高疗效,减缓耐药株的产生,有效控制感染。Objective To investigate the clinical distribution and drug resistance of 116 strains of Acinetobacter baumanii in our hospital and to offer reference for clinical therapeutics.Methods The infection distribution and the susceptibility results of 116 strains of Acinetobacter Baumanii were analyzed retrospectively from hospitalized patients during Feb.2009 to Feb.2010 and identified by VITEK-32 System of drug susceptibility.The results were assessed with NCCLS.Results The highest appearing rate of Acinetobacter baumannii strains was in sputum（86.10%）,the second was in the wound secretion.ICU ward showed the highest proportion of Acinetobacter baumanii,followed by the departments of neurosurgery and respiration.In the results of the sensitivity to antibiotics,Acinetobacter baumannii strains had the highest drug resistance rate to cefoxitin（95.60%）,the lowest resistance rate to imipenem（3.60%）.The drug resistance rates to ticarcillin clavulanic,cefoperazone sulbactam,amoxicillin clavulanate were 23.60%,32.40% and 34.70% respectively,which also had high resistant to other 14 kinds of tested antibiotics.Moreover these strains showed multi-drug resistance.Conclusion Acinetobacter baumanii mainly causes lower respiratory tract infection.The sensitivity drugs are few.Imipenem is the primary choose to treat the infections caused by Acinetobacter baumannii.It is important to enhance the surveillance of Acinetobacter baumannii,select rational antibiotic drugs correctly according to the results of antibiotics susceptibility tests to improve drug action,delay the occurrence of bacteria resistance and control the infection effectively.

关 键 词：鲍曼不动杆菌 感染分布 耐药性 微生物敏感性 

分 类 号：R915[医药卫生—微生物与生化药学] R969.3[医药卫生—药学]