Grave's病再次^(131)I治疗时间的选择  

Time for second radioisotope therapy of Grave's disease

作　　者：李飞[1] 司宏伟[2] 岳峤[2] 赵学峰[2] 徐慧琴[2] 

机构地区：[1]安徽医科大学第二附属医院核医学科,安徽合肥230601 [2]安徽医科大学第一附属医院核医学科,安徽合肥230022

出　　处：《安徽医药》2011年第1期46-48,共3页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省自然科学基金资助项目(No090413132)

摘　　要：目的探讨Grave’s病患者再次131碘治疗时间。方法回顾2007年2月1日～2010年4月30日期间接受131I治疗、且随访近1年左右的48例G rave’s甲亢患者,记录患者年龄、性别及4次随访结果(FT3、FT4、TSH),以评估患者疗效及转归。结果 4次随访时间分别为(103.6±21.9)、(188.2±46.3)、(300.1±80.9)、(476±142.9)d。治疗半年后治愈和甲减患者数量相对稳定,分别维持在27%和66%左右。末次随访时患者治愈率93.7%,甲状腺功能减退发生率62.5%,复发率6.3%,甲状腺功能正常者占31.3%。第1次随访的复发、治愈和甲减患者均可在病程中出现复发、治愈和甲减,其中第1、2次随访时患者病情变化较大,第3、4次随访病情则较平稳。结论单次小剂量131I治疗6个月后,患者整体复发率、治愈率和甲减率均较稳定,且个体甲状腺激素水平也趋于稳定,应于此时给予第二次131I治疗。Aim To investigate the time of second 131I radioisotope therapy for Grave＇s disease.Method During Feb 1st 2007 and Apr 30 th 2008,48 patients with Grave＇s disease underwent 131I radioisotope therapy,and were followed up about 1 year in our department.Retrospective study was made on them.Their age,sex and results（FT3,FT4 and TSH）were recorded for further evaluation.Results The four follow-up period of these patients were 103.6±21.9,188.2±46.3,300.1±80.9 and 476±142.9 days respectively.Six months later,the amount of cured and hypothyroidism patients were relatively stable at the level of 27% and 66%.During the 4th follow-up peried cured rate was 93.7%,hypothyroidism rate 62.5%,relapse rate 6.3%,and the rate of patients with normal thyroid hormone was 31.3%.In the 1st follow-up period,each cured,relapse and hypothyroidsm patients can migrate to other groups in their course of disease.The patients＇conditions were more likely to change during the 1 st and second follow-up period,and stable during 3rd and 4th one.Conclusion Six months after single low-dose 131I radioisotope therapy,patients＇ relapse,cured and hypothyroidism rates were stable,and individual thyroid hormone rate was also stable and suitable for the second radioisotope therapy.

关 键 词：Grave's甲亢 131碘治疗 甲状腺功能减退 

分 类 号：R581.1[医药卫生—内分泌]