阿维菌素原药对昆明小鼠体液免疫功能的影响  

The effect of avermectin on humoral Immunity of KM Mice

作　　者：左派欣[1] 姜红[1] 张俊刚[1] 洪丽华[1] 

机构地区：[1]河北省疾病预防控制中心,石家庄0500021

出　　处：《医学动物防制》2011年第1期42-43,共2页Journal of Medical Pest Control

摘　　要：目的探讨阿维菌素原药对小鼠体液免疫功能的影响。方法阿维菌素设3个剂量组20、10、5mg/kg和阴性对照组,连续给昆明小鼠染毒28d,进行抗体生成细胞(PFC)和半数溶血值(HC50)测定来评价对体液免疫功能的影响;小鼠取血测WBC、TP、白蛋白(又称清蛋白,album in,A lb)、IgG、IgM。结果 20mg/kg组抗体生成细胞数(PFC)和半数溶血值(HC50)均明显降低,和阴性对照组差异有统计学意义(P<0.01);20mg/kg组WBC、TP、ALB、IgG、IgM均比阴性对照组明显降低,差异有统计学意义(P<0.05)。结论阿维菌素原药对昆明小鼠的体液免疫功能有一定的抑制作用。Objective To study the avermectin effect on humoral immunity of KM mice.Method Avermectin was gavaged to the mice for 28 days at dose of 20、10、5mg/kg and negative group.The humoral immunity function was evaluated by antibody-producing cells and HC50.Mainwhile,determination WBC、TP、ALB、IgG、IgM which were from blood.Results At 20mg/kg group,antibody-producing cells and HC50 declined significantly and it had significant difference compared with negative control group﹙P0.01﹚,and WBC、TP、ALB、IgG、IgM declined than negative group and had significant difference too﹙P0.05﹚.Conclusions Avermectin have immuneity inhibition on KM mice in some certain.

关 键 词：阿维菌素 鼠 体液免疫 

分 类 号：R392[医药卫生—免疫学]