陈氏内异丸对子宫内膜异位症大鼠血浆PGE2及PGF2α浓度的影响  

Effect of Neiyi Pill of CHEN on PGE2,PGF2α of endometrioc tissue in the rat

作　　者：邬素珍[1] 赵春梅[1] 聂润球[1] 

机构地区：[1]广州中医药大学附属佛山市中医院,佛山528000

出　　处：《中华中医药杂志》2011年第2期357-359,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广东省中医药管理局资助项目(No.1060007)~~

摘　　要：目的:观察陈氏内异丸对子宫内膜异位症(endometriosis,EMs)大鼠血浆前列腺素E2(prostaglandin E2,PGE2)和前列腺素F2α(prostaglandin F2α,PGF2α)浓度的影响,探讨陈氏内异丸治疗EMs的作用机制。方法:建立EMs大鼠模型并将造模成功的大鼠随机分组,分别给予陈氏内异丸高、中、低剂量药液及达那唑混悬液、蒸馏水灌胃4周。观察治疗前后血PGE2及PGF2α浓度的变化。结果:①治疗后陈氏内异丸各治疗组和达那唑组PGE2、PGF2α浓度明显低于模型组(P<0.05);②高、中剂量组PGE2浓度低于低剂量组及达那唑组(P<0.05);③高、中剂量组及达那唑组PGF2α浓度均低于低剂量组(P<0.05)。结论:陈氏内异丸能降低EMs大鼠血PGE2和PGF2α的浓度,这可能是其治疗子宫内膜异位的有效机制之一。Objective： To evaluate the effect of Neiyi Pill of CHEN on PGE2,PGF2αof endometrioc tissue in the rat and probe into the mechanism.Methods： To establish endometriosis model in rats.The SD rats were divided into randomly five groups： Neiyi Pill of CHEN high-dose group（HDG）,middle-dose group（MDG）,low-dose group（LDG）,Danazol group（DG）,model group and SG operation group（SG）.After four weeks＇ treatment,all the rats were observed the levels of PGE2 and PGF2α in the blood.Results： Compared with model group,the levels of PGE2 and PGF2α in the blood in very group of Neiyi Pill of CHEN and DG were reduced significantly in post four weeks（P0.05）.And the level of PGE2 and in the blood in HDG and MDG was lower than that in LDG and DG（P0.05）.Moreover compared with SG,there were no difference between the HDG and the MDG.The level of PGF2α in HDG,MDG and DG were lower than that in LDG（P0.05）.And compared with SG,there were no difference between the three groups（P0.05）.Conclusion： Neiyi Pill of CHEN can reduce the levels of PGE2 and PGF2α in the blood.Neiyi Pill of CHEN with high-dose and middle-dose can make the higher concentration return to normal level and the effect was better than the low-dose.Danazol had the same therapeutic effect.Moreover Neiyi Pill of CHEN with high-dose and middle-dose in the effect in PGE2 were better than Danazol.

关 键 词：子宫内膜异位症 陈氏内异丸 大鼠 前列腺素 

分 类 号：R285.5[医药卫生—中药学]