加用神经节苷脂治疗脑挫裂伤39例疗效观察  

Observation of Monosialoganglioside-1 in 39 Cases of Cerebral Contusion and Laceration

作　　者：罗文忠[1] 杨志明[1] 孟永良[1] 胡帮洪[1] 李志强[1] 高翔荣[1] 邱戈[1] 陈勇吉[1] 

机构地区：[1]崇州市人民医院,四川成都611230

出　　处：《现代临床医学》2011年第1期26-27,共2页Journal of Modern Clinical Medicine

摘　　要：目的:探讨神经节苷脂治疗脑挫裂伤的疗效及安全性。方法:将78例脑挫裂伤患者随机分为治疗组和对照组,各39例。对照组给予脱水、一般营养神经药物等常规治疗,治疗组在对照组治疗的基础上加用单唾液酸四己糖神经节苷脂注射液(Monosialogangliosides-1,GM-1)60 mg.d-1治疗。治疗后第2周由专业医师进行神经功能缺损(NFD)评定、日常生活能力(ADL)评定及药物安全性评定。结果:治疗后治疗组神经功能缺损改善程度和日常生活活动能力均明显高于对照组(P<0.05),治疗组用药前后肝肾功能、血常规对比无显著性差异(P>0.05)。结论:神经节苷脂能有效地促进脑挫裂伤患者的神经功能恢复和提高患者的日常生活能力,且无明显副作用。Objective：To explore the treatment effect and safety of Monosialoganglioside-1 on cerebral contusion and laceration.Methods：78 cases of cerebral contusion and laceration were randomly divided in two groups：39 treatment groups and 39 control groups.The control groups were gived dehydration and general nutrition neural drugs treatments,The treatment groups were gived general treatment and Monosialoganglioside-1 joined in 100 mL physiological saline treatment,once a day.NFD,ADL and drugs safety were evaluated by professional doctors before treatment and after two weeks.Results：NFD and ADL of two groups patients before treatment were not significant difference（P0.05）.The neurologic deficits and daily life activities of the treatment groups were higher to the control groups（P0.05）.For treatment groups,liver function,kidney function and blood were not significant difference before treatment and after treatment.Conclusion：In cerebral contusion and laceration cases Monosialoganglioside-1 can effectively promote neurological recovery and improve the ability of daily life,and no side effects.

关 键 词：脑挫裂伤 神经节苷脂 神经功能 日常生活能力 安全性 

分 类 号：R651.15[医药卫生—外科学]