轻度胃肠炎伴婴幼儿惊厥患儿粪便及脑脊液轮状病毒及诺沃克病毒的检测及意义  

The detection of Rotavirus and Norwalkvirus in stool and cerebrospinal fluid of children with infantile convulsions associated with mild gastroenteritis

作　　者：路新国[1] 廖建湘[1] 周桂芬[1] 胡雁[1] 李冰[1] 韩春锡[1] 黄铁栓[1] 

机构地区：[1]中国医科大学深圳儿童医院,518026

出　　处：《中国小儿急救医学》2011年第1期39-40,共2页Chinese Pediatric Emergency Medicine

摘　　要：目的探讨轻度胃肠炎伴婴幼儿惊厥常见感染病原及轮状病毒（RV）、诺沃克病毒（NoV）导致惊厥发生的差异。方法用RT—PCR方法对30例轻度胃肠炎伴婴幼儿惊厥患儿的大便及脑脊液中RV、NoV进行检测，分析两种病毒所导致惊厥发作频率的差异。结果30例中，RV粪便阳性17例（56．7％），脑脊液阳性3例（17．7％）；NoV粪便阳性6例（25．0％），脑脊液阳性1例（16．7％）。NoV感染患儿惊厥的发生次数为（4．33±1．75）次，明显高于RV感染患儿[（2．53±1．12）次]，差异有非常显著性（P〈0．01）。脑脊液中病毒阳性患儿的惊厥发生次数为（4．75±1．71）次，明显高于阴性患儿[（2．63±1．21）次]（P〈0．01）。结论RV、NoV是导致轻度胃肠炎伴婴幼儿惊厥的常见病原；NoV感染对中枢神经系统的影响程度可能大于RV感染；脑脊液中病毒存在可能与惊厥的频繁发生有关，其具体机制有待进一步研究。Objective To explore the common pathogen of infantile convulsions associated with mild gastroenteritis, and to study the differences between the seizures caused by the two kinds of virus. Methods RT-PCR was used to detect Rotavirus （RV） and Norwalkvirus （NoV） in stool and cerebrospinal fluid of 30 cases with infantile convulsions associated with mild gastroenteritis. The differences between the frequency of seizures caused by two kinds of virus were analyzed by statistical methods （two-sample t-test）. Results 17/30 （ 56. 7% ） were RV-positive in stool and 3/17 （ 17. 7% ） in cerebrospinal fluid; 6/30 （25.0%） were NoV-positive in stool and 1/6 （ 16.7% ） in cerebrospinal fluid. The seizure frequency with NoV infection was （4. 33 ± 1.75） times,and RV infection patients was （2. 53 ± 1.12） times （P 〈0. 01 ）. The seizure frequency of CSF virus-positive children was （4. 75 ± 1.71 ） times compared to （2. 63 ± 1.21 ） times in virus-negative children （ P 〈 0. 01 ）. Conclusion The common pathogens causing infantile convulsions associated with mild gastroenteritis were RV and NoV. The degree of NoV infection affecting the central nervous system may be greater than RV. The presence of the virus in cerebrospinal fluid may lead to higher incidence of seizures, but their exact roles related to the occurrence of seizures remain to be further studied.

关 键 词：胃肠炎 惊厥 轮状病毒 诺沃克病毒 婴幼儿 

分 类 号：R72[医药卫生—儿科]