“肤敏”膏抑制小鼠变应性接触性皮炎机制的研究  

Experimental Study on "Fu Min" Gao Inhibiting Allergic Contact Dermatitis in Murine Model

作　　者：李静平[1] 李庆生[1] 李杰[2] 

机构地区：[1]云南中医学院,云南昆明650500 [2]南方医科大学,广东广州510515

出　　处：《中华中医药学刊》2011年第2期389-390,共2页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:研究"肤敏"膏滋剂对小鼠变应性接触性皮炎(ACD)的抑制作用,探讨其作用机理。方法:以DNFB和FITC分别建立小鼠ACD模型,采用ELISA法检测ACD小鼠产生干扰素-γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)、白介素4和6(IL-4、IL-6)的水平及"肤敏"膏对4种细胞因子的作用。结果:口服不同剂量"肤敏"膏对4种细胞因子均有显著或不同程度的抑制作用(P<0.05或P<0.01)。结论:"肤敏"膏对小鼠ACD疗效可能通过抑制Th1/Th2细胞因子而发挥作用。Objective：To investigate the mechanism of ＂Fu Min＂ Gao inhibiting al/ergic contact dermatitis （ACD） in murine model. Methods ：The routine model of allergic comaet dermatitis by topical DNCB and FITC were used. After oral administration of ＂Fu Min＂ Gao in different doses, The levels of IFN -γ,TNF α,IL-4 and IL-6 in the serum of these mice were detected by enzyme-linked immunosorbent assay （EL/SA）. Result ：Different doses of ＂Fu Min＂ Gao inhibited the expression of these four eytokines to different degrees. （ P 〈 0.05 or P 〈 0.01 ）. Conclusion ： The therapeutic effect of ＂Fu Min＂ Gao on murine ACD may be played by inhibiting the expression of some cytokines of helper T lymphocyte.

关 键 词：皮炎 变应性接触性 细胞因子类 “肤.敏”膏 

分 类 号：R285.5[医药卫生—中药学]