部分食管癌高发区水的诱变性分析  

Mutagenic Analysis of Water in The Areas with High-incidence of Esophageal Cancer

作　　者：宋悦红[1,2] 韩建英[2] 谭家驹[3] 周舫[1] 

机构地区：[1]郑州大学公共卫生学院,河南省郑州市361021 [2]安阳市疾病预防控制中心 [3]佛山市第一人民医院

出　　处：《职业与健康》2011年第4期420-422,共3页Occupation and Health

基　　金：国家863项目(2009AA022421)

摘　　要：目的分析部分食管癌高发区各种水的致突变性及致癌性。方法采用蚕豆根尖细胞微核试验作为化学致突变物、致癌物的初筛试验。结果各种类型的水样诱发的蚕豆根尖细胞微核率分别为:煤矿排污水14.42‰,红旗渠水8.62‰,河水8.34‰,深机井水2.81‰,自来水3.96‰。结论煤矿排污水诱变性最高,其次是红旗渠水源水和浊漳河水,而林州市深机井水和自来水诱变性较低。提示,饮用高诱变水可能是食管癌的危险因素之一。[Objective] To analyze the mutagenicity and carcinogenicity of all kinds of water in the areas with high-incidence of esophageal cancer.[Methods]Micronucleus test in Vicia faba root tips cell was adopted for primary screening test of chemical mutagens and carcinogens.[Results]The rate of Vicia faba root tip micronucleus caused by different types of water samples was14.42‰ of coal mine waste water,8.62‰ of Red Flag Canal water,8.34‰ of river water,2.81‰ of deep phreatic water,3.96‰ of tap water,respectively.[Conclusion]Mutagenicity of coal mine waste water is the highest,followed by the Red Flag Canal source water and water of Zhuozhang River.The mutagenicity of deep phreatic water and tap water in LinZhou City is much lower,It indicates that drinking the high mutagenicity water may be a of the risk factor of esophageal cancer.

关 键 词：食管癌 蚕豆根尖细胞微核实验 水的诱变性 

分 类 号：R123[医药卫生—环境卫生学]