重型脑外伤患者术中使用乌司他丁后对血清s-100β含量的影响  

Influence of Ulinastatin on Serum s-100β Content in Patients with Severe Cerebral Trauma

作　　者：张序忠[1] 薛晓燕[1] 吴安生[1] 刘凌云[1] 

机构地区：[1]浙江省瑞安市人民医院,浙江瑞安325200

出　　处：《中国现代医生》2011年第2期12-13,共2页China Modern Doctor

摘　　要：目的对比观察重型脑外伤患者术中使用乌司他丁后对血清s-100β含量的影响。方法选取104例重型颅脑外伤的手术患者(GCS<8分)随机分成实验组和对照组,术中对照组常规麻醉手术方法,实验组在麻醉诱导后手术开始前给予乌司他丁20万单位,在不同的时间段分别抽取两组静脉血,利用血清s-100蛋白酶联免疫吸附法试剂盒测定血清S100蛋白的浓度。同时观察两组患者的术后平均住院天数、生命体征和并发症情况。结果实验组血清s-100β含量低于对照组,且术后并发症发生率较对照组少,住院时间短(P<0.05)。结论重型脑外伤患者术中使用乌司他丁后能起到较好的对脑组织的保护作用。Objective To compare and observe the influence of ulinastatin on serum s-lO0β content in patients with severe cerebral trauma. Methods 104 cases of patients with severe cerebral trauma （GCS〈8） were selected and randomly divided into experimental group and control group. During surgery, the control group was carried out with conventional anesthesia;The experimental group was treated with ulinastatin （200 thousand units）,and the venous blood of the two groups were colected at different time points. The concentration of s-100β in serum was determined with s-100β ELISA kit. The average hospitalization days,vital signs and complications were observed. Results The experimental group had lower concentration of s-10Oβ in serum,less complication rate and shorter hospitalization time than those of control group（P〈O.05）. Conclusion Ulinastatin treated during operation in patients with severe cerebral trauma has good protective effect for brain tissue.

关 键 词：乌司他丁 重型脑外伤 血清S-100Β 

分 类 号：R651.1[医药卫生—外科学]