骨髓中IL-7、IL-7R及EBF表达与运动性免疫抑制  

Expression of IL-7、IL-7R and EBF in the bone marrow & exercise-induced immune suppression

作　　者：耿青青[1] 郝选明[2] 

机构地区：[1]山东体育学院基础理论系,山东济南250102 [2]华南师范大学体育科学学院,广东广州510006

出　　处：《体育学刊》2011年第1期139-144,共6页Journal of Physical Education

基　　金：广东省自然科学基金项目资助(9151063101000059)

摘　　要：IL-7在早期B细胞的增殖中起到了关键的促进作用,EBF在淋巴系干细胞向B系细胞分化中起着决定性的系谱特异定型作用。IL-7、IL-7R通过维持EBF表达,参与了B细胞增殖转录因子网络的形成,这与早期B细胞分化调控密切相关。运动中GC的升高会加快早期发育中B细胞的凋亡,研究B细胞的发育及其调控机制对寻求更有效的运动免疫调理措施具有重要意义。IL-7 is an important cytokine for B lymphocytes development and can promote B lymphocytes progeni-tors transition and.Expression of EBF is critical for the lineage specification at the early stage of B cell develop-ment.IL-7 and IL-7R are participants in the formation of the transcription factor network during B lymphopoiesis by maintaining the EBF expression level above a certain threshold.These are necessary for further transition of B cell progenitors.Elevated GC in exercise induces rapidly apoptosis in developing B lymphocytes.It is important and practical for athletes,immune modification to study the lymphocyte development and its regulation.

关 键 词：运动免疫学 骨髓 B淋巴细胞 白细胞介素7 白细胞介素7受体 早期B细胞因子 综述 

分 类 号：G804.7[文化科学—运动人体科学]