颈动脉粥样硬化斑块与血浆纤维蛋白原的关系  

Relationship between Carotid Atherosclerotic Plaque and Plasma Fibrinogen

作　　者：戴志刚[1] 王涛[2] 武文元[2] 

机构地区：[1]内蒙古医学院附属人民医院神经内科,内蒙古自治区呼和浩特市010020 [2]内蒙古医学院附属医院

出　　处：《职业与健康》2011年第3期248-250,共3页Occupation and Health

基　　金：内蒙古自治区卫生厅医疗卫生科研计划项目(2005077);内蒙古自治区自然基金资助项目(20080404MS1126)

摘　　要：目的探讨患者颈动脉粥样硬化程度以及颈动脉粥样硬化性质与血浆纤维蛋白原的关系。方法对存在颈动脉粥样硬化的65例患者进行颈动脉彩色多普勒检查,记录颈动脉粥样硬化斑块的部位、回声强度、颈总动脉分叉处内膜中层厚度及血管内径,并根据颈动脉狭窄程度分为4组,再根据超声检查动脉硬化斑块性质分为硬斑和软斑2组,同时检测血浆纤维蛋白原水平,进行统计学分析。结果随着血浆纤维蛋白原水平的升高,动脉粥样硬化狭窄程度也随之增加,且呈正相关;中、高浓度纤维蛋白原组软斑发生率明显多于低浓度组。结论血浆纤维蛋白原水平与颈动脉粥样硬化斑块的性质有关,血浆纤维蛋白原可能决定了颈动脉粥样硬化斑块稳定性。而且血浆纤维蛋白原升高与颈动脉粥样硬化密切相关,可能在颈动脉粥样硬化的发生发展中起着重要的作用。[Objective]To study the relationship between carotid atherosclerosis and plasma fibrinogen.[Methods]Color Doppler was carried out on carotid artery of 65 carotid atherosclerotic patients,recording position,echo intensity of artherosclerotic plaque,carotid artery intima-media thickness and vessel inside diameter.According to carotid artery stenosis,the patients were divided into 4 groups,and were re-divided into 2 groups（hard plaque and soft plaque） on the basis of character of atherosclerotic plaque,meanwhile,detecting the level of plasma fibrinogen,and performing statistical analysis.[Results]With the increasing level of plasma fibrinogen,the degree of carotid atherosclerotic stenosis was increased,showing positive correlation;the rate of plasma fibrinogen soft plaque of middle and high density groups is obviously higher than the lower density group.[Conclusion]Plasma fibrinogen level is closely correlated with characteristic of carotid atherosclerotic plaque.Plasma fibrinogen may determine the stability of carotid atherosclerotic plaque.And the increasing level of plasma fibrinogen is closely related with carotid atherosclerosis and plays an important role in its development.

关 键 词：纤维蛋白原 颈动脉 动脉粥样硬化 超声多普勒 

分 类 号：R543.5[医药卫生—心血管疾病]