米索前列醇对预防阴道分娩产后出血的研究  

STUDY OF MISOPROSTOL FOR THE PREVENTION OF POSTPARTUM HEMORRHAGE IN VAGINAL DELIVERY

作　　者：陈红[1] 雷少霞[1] 王碧霞[1] 熊文梅[1] 卢德梅[2] 

机构地区：[1]佛山市禅城区张槎医院 [2]佛山市妇幼保健院

出　　处：《现代医院》2011年第1期12-14,共3页Modern Hospitals

基　　金：佛山市卫生局医学科研立项课题(编号:2010187)

摘　　要：目的探讨米索前列醇对预防阴道分娩产后出血的效果。方法将入选的200例具有产后出血高危因素的产妇,随机分为米索前列醇组(米索组)100例,在胎儿娩出后即舌下含服米索前列醇200 ug,对照组(缩宫素组)100例在胎儿娩出后立即静注缩宫素10 u。分别观察两组产妇第三产程时间、产后2 h出血量、产后出血发生率,测量并记录舌下含服米索前列醇前后血压变化情况。结果米索组第三产程时间、产后2 h出血量、出血率明显少于对照组(p<0.01),用药前后的血压差异无统计学意义(p>0.05)。结论米索前列醇具有比缩宫素更强的子宫收缩作用,能减少产后出血量,而舌下给药方法更为简便,更适合于基层医院。Objective To observe the effects of misoprostol for prevention of postpartum hemorrhage （PPH） in vaginal delivery. Methods Two hundreds pregnant women, who have high risk factors for PPH, were randomized into two groups ： misoprostol group （ n = 100 ） , given 200ug sublingual misoprostol immediately after fetal disengage- ment, control group （ n = 100） , given 10 IU intravenous oxytocin immediately after delivery of the neonate. To observe duration of the third stage labour, the amount of bleeding within two hours after delivery and bleeding rate between the two groups. At the same time to measure and record changes in blood pressure before and after sublingual misoprostol and adverse effects. Results Duration of the third stage labour, the amount of bleeding within two hours after delivery and bleeding rate was significantly lower in the misoprostol group than in the oxytocin group（p 〈 0, 01 ）. There was no significant difference on blood pressure before and after sublingual misoprostol and side effect between the two groups （p 〉 0. 05）. Conclusion Misoprostol appears to be more effective in reduction of PPH than that of oxytocln. Sublin- gual administration is more convenient and suitable for primary hospital.

关 键 词：阴道产 出血量 米索前列醇 缩宫素 

分 类 号：R97[医药卫生—药品]