反复呼吸道感染对患儿体液免疫功能的影响  

Effect of Humeral Immune Functions in Sick Children with Recurrent Respiratory Infection

作　　者：文忠[1] 

机构地区：[1]广东肇庆市第一人民医院,广东肇庆526021

出　　处：《中国医药指南》2011年第5期23-25,共3页Guide of China Medicine

摘　　要：目的探讨反复呼吸道感染(RRI)与免疫球蛋白和IgG亚类的关系。方法选取2006年8月至2010年8月符合RRI诊断标准的儿童74例作为RRI组,采用免疫散射比浊法检测血清IgG、IgA、IgM及IgG亚类水平,并与对照组(非RRI的急性呼吸道感染患儿)和正常组进行比较。结果对照组血清IgM水平高于正常组,差异有统计学意义(P<0.05)。RRI组血清IgGI、gA水平低于正常组(P<0.05)。RRI组血清IgG2和IgG4水平低于正常组(P<0.05)。对照组血清IgG3水平低于正常组(P<0.05)。结论 RRI普遍存在暂时性体液免疫功能低下;对RRI患儿同时检测血清免疫球蛋白及IgG亚类具有重要意义。Objective To investigate the relationship between recurrent respiratory infection（RRI） with immunoglobulin and immunoglobulin G subclass.Methods 74 children with recurrent respiratory tract infection from our hospital were randomly chosen as the study subjects as RRI group from Aug 2006 to Aug 2010.The changes of serum levels of IgG、IgA、IgM and immunoglobulin G subclass was detected by immune scatter turbidimetry compared with the control group（children with acute respiratory infections but not RRI who hospitalized in the same period） and the normal group.Results The level of IgM in control group was obviously higher than that of normal group（P0.05）.The level of IgG、IgA、IgG2 and IgG4 in RRI group was lower than that of normal group.Conclusion Temporary humeral immunity retardation exists widely in RRI;and the detection of immunoglobulin and immunoglobulin G subclass has important significance in children with RRI

关 键 词：反复呼吸道感染 体液免疫 免疫球蛋白 IGG亚类 儿童 

分 类 号：R446.6[医药卫生—诊断学]