Ⅱb型高血脂症患者MTHFR C677T基因多态性研究  

Study on MTHFR C677T gene polymorphism in patients with Ⅱb hyperlipidemia

作　　者：莫和国[1] 尹志农[2,3] 王俊文[2,3] 王红敏[2,3] 

机构地区：[1]南方医科大学附属小榄医院检验科,广州528415 [2]北京市垂杨柳医院 [3]上海同济大学附属北京微创医院实验中心,100022

出　　处：《国际检验医学杂志》2011年第1期40-41,43,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨亚甲基四氢叶酸还原酶C677T基因多态性与Ⅱb型高血脂症的相关性。方法采用TaqMan探针法检测101例Ⅱb型高血脂症患者和150健康体检者MTHFR C677T基因多态性,同时检测血脂和同型半胱氨酸水平。结果Ⅱb型高血脂症组TC、TG、LDL-C、HCY水平均高于健康对照组,差异有统计学意义(P<0.01);同时Ⅱb型高血脂症组CT、TT基因型频率明显高于健康对照组,差异有统计学意义(χ2=6.597,P=0.01)。携带CT、TT基因型个体发病风险是CC基因型的2.4倍(95%CI:1.2161～4.685)。结论 MTHFR C677T基因多态性与Ⅱb型高血脂症发病风险相关联。Objective To explore the relationship between MTHFR C677T gene polymophism and IIb hyperlipidemia and as- sess serum lipid and plasma homocysteine levels. Methods MTHFR C677T gene polymophism of 101 cases withⅡb hyperlipi- demia and 150 normal control were detected by TaqMan proble. Results The TC,TG.LDL-C,HCY levels with Ⅱb hyperlipidemia group were significantly higher than that in control group （P〈01 01）,and at the same time the frequencies of CT,TT genotypes with Ⅱb hyperlipidemia group were also significantly higher than that in control group（x2= 6. 597, P = 0.01）. The CT, TT individual risk with Ⅱb hyperlipidemia group is 2.4 times of the CC genotype. Conclusion These findings supported the hypothesis that genetic polymorphisma in MTHFR C677T contributed to the development of Ⅱb hyperlipidemia.

关 键 词：亚甲基四氢叶酸还原酶(NADPH) 高血脂症 基因多态性 

分 类 号：R589.2[医药卫生—内分泌]