血清载脂蛋白A5水平与糖尿病大血管病变的关系  

Relationship between serum concentrations of apolipoprotein A5 and pathogenesis of macrovascular complication in type 2 diabetes mellitus

作　　者：秦维超[1] 

机构地区：[1]湖北省十堰市人民医院检验科,442008

出　　处：《国际检验医学杂志》2011年第1期45-46,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨血清载脂蛋白A5(ApoA5)水平与2型糖尿病及其合并大血管病变患者的关系。方法将265例2型糖尿病患者按一定的纳入标准,分成不伴血管病变组134例和合并大血管病变组131例;另抽取100名健康体检者作为健康对照组。采用酶联免疫吸附法测定血清ApoA5水平,并进行相关性分析。结果 2型糖尿病合并大血管病变患者血清ApoA5水平与不伴大血管病变组比较,差异具有统计学意义(P<0.05);且显著高于健康对照组,差异有统计学意义(P<0.05)。另相关分析结果显示,ApoA5与三酰甘油水平呈显著负相关(r=-0.201,P<0.05)。结论 ApoA5水平在2型糖尿病合并大血管病变患者中明显降低,可能是导致2型糖尿病及合并大血管病变的重要危险因素。Objective To investigate the serum apolipoprotein A5 concentrations in the pathogenesis of type 2 diabetes mellitus （T2DM） and its macrovascular complications, to study the relation between apoli-poprotein A5 and diabetes mellitus and it＇s macro- vascular complication. Methods ELISA assay was applied to test serum apolipoprotein A5 levels, which were determined in 265 T2DM patients（with macrovascular complications 131 cases respectively） and 100 healthy controls, Results There was a significant difference of apolipoprotein A5 levels between T2DM patients and without maerovaseukar complication. They were significantly elevated in patients with T2DM as compared with control subjeets（P〈0.05）. Univariate linear regression analysis showed significant negatively correlations between serum apolipoprotein A5 with TG（r-=-0. 201, P〈0.05）. Conclusion In patients with T2DM, serum apolipoprotein A5 concentrations are greater than in non-diabetic subjects. It play important roles in the initiation and development of T2DM. The study suggested that apolipoprotein A5 might be an important independent risk factor.

关 键 词：载脂蛋白A类 糖尿病 2型 大血管病变 

分 类 号：R587.2[医药卫生—内分泌]