2-[(2,6-二氯苯基)氨基]苯乙酸稀土配合物的合成及抗炎镇痛活性研究  

Syntheses and anti-inflammatory analgesic activity of rare earth complexes with 2-[(2,6-dichlorophenyl) amino] benzeneacetic acid

作　　者：徐桂清[1] 杨军英[2] 张鹏[1] 韩会娟[3] 郝二军[1] 李伟[1] 

机构地区：[1]河南师范大学化学与环境科学学院,河南新乡453007 [2]河南师范大学生命科学学院,河南新乡453007 [3]河南科技学院化学化工学院,河南新乡453007

出　　处：《化学研究与应用》2011年第2期194-198,共5页Chemical Research and Application

基　　金：河南省自然科学研究计划项目(2010B150016)

摘　　要：合成了5种2-[(2,6-二氯苯基)氨基]苯乙酸稀土配合物,通过元素分析、EDTA-滴定、摩尔电导、红外光谱,确定了配合物的组成为REL3(RE=La、Ce、Nd、Sm、Gd,L=2-[(2,6-二氯苯基)氨基]苯乙酸)。采用小鼠耳肿胀实验、血管通透性实验研究了其抗炎活性,采用扭体实验及热板实验研究了其镇痛活性。结果表明,与阳性对照药2-[(2,6-二氯苯基)氨基]苯乙酸钠相比,部分配合物具有更强的抗炎镇痛活性。Five rare earth metal（III） complexes REL3（HL= 2-[（2,6-dichlorophenyl）amino] benzeneacetic acid;RE=La,Ce,Nd,Sm,Gd） were prepared and characterized by elemental analysis,complexometric titration,thermal analysis,molar conductivity,IR and UV.Mice ear swelling induced by xylene and capillary permeability test were used to evaluate the antiinflammatory activity.The analgesic activity were performed with writhing response caused by acetic acid and mice hot-plate test.The results showed that compared with NaL,the antiinflammatory analgesic activity of some complexes were superior.

关 键 词：稀土配合物 合成 抗炎镇痛活性 

分 类 号：O641.33[理学—物理化学]