呼吸道病毒感染诱发哮喘的预防  

Clinical prevention of respiratory tract viral infection-induced asthma attacks:random and control trial

作　　者：肖平[1] 常晶[1] 周奇兴 程克文[3] 张有志[1] 唐平[1] 

机构地区：[1]上海市杨浦区市东医院呼吸科,上海200438 [2]上海市普陀区利群医院,上海200060 [3]复旦大学附属华山医院宝山分院,上海200052

出　　处：《临床肺科杂志》2011年第3期344-346,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨预防呼吸道病毒感染诱导哮喘发作方法的有效性和安全性。方法 258哮喘缓解期患者随机分为对照组（A组,87例）和试验组（B组,171例）,患者出现急性上感症状后3天内来诊,B组于就诊当天即予：大剂量的吸入性糖皮质激素和抗胆碱能药物,用药3~7 d。两组哮喘发作按常规处理,随访观察7~14 d。结果两组各失访3例,B组出现声音嘶哑3例。最终观察84例A组患者,哮喘发作48例（57.1%）,轻度18例,中度21例,重度9例,165例B组患者,哮喘发作54例（32.7%）,轻度30例,中度24例,无重度发作。A、B两组哮喘发作情况差异有统计学意义（P〈0.05）。结论在病毒感染诱导哮喘发作窗内给予大剂量吸入激素及抗胆碱能药物可有效而安全的避免相当多的哮喘患者发作。Objective To investigate the efficacy and safety of prevention for respiratory tract viral infection-induced asthma attacks.Methods 258 subjects were randomly divided into control group（group A,87）and experiment group（group B,171）.No measure was provided for group A before asthma attacks,but routine measure after asthma attacks;A large dosage of ICS and anticholinergic bronchodilators were given for group B in the window（3 days）and additional β-agonists after asthma attacks.All the patients were followed for 7~14 days.Results 3 cases was lost in every group and three patient was hoarse in group B.Asthma attacks rate was 51.7% in group A：mild asthma attacks were in 18 patients,moderate in 21,and severe in 9.Asthma attacks rate was 32.7% in group B：mild asthma attackswere in 30 patients and moderate in 24.Asthma attacks in group B were decreased significantly when compared with group A（P0.05）.Conclusions A large amounts of asthma patients will be avoided to exacerbate if a large dosage ICS and anticholinergic bronchodilators provided for them in the window.

关 键 词：上呼吸道病毒感染 哮喘 急性发作 预防 

分 类 号：R725.6[医药卫生—儿科]