白介素10与阻塞性睡眠呼吸暂停低通气综合征  

Expression of interleukin 10 in patients with obstructive sleep apnea hyponea syndrome

作　　者：朱会芬 张冬会[2] 邢邯英[2] 司翠权 

机构地区：[1]无极县医院,河北无极052460 [2]河北省人民医院临床医学研究中心,河北石家庄050051

出　　处：《临床肺科杂志》2011年第3期357-358,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的了解阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清白介素10(IL-10)、一氧化氮(NO)及C反应蛋白(CRP)水平的变化,探讨OSAHS的发病机制。方法选取男性35例经多导睡眠图监测确诊的重度OSAHS患者为实验组,25例年龄、体重指数等均相匹配的健康查体者为对照组,用ELISA检测血清中IL-10、NO及CRP的水平。结果 OSAHS组NO及CRP水平显著高于健康对照组(P<0.01),而IL-10水平低于健康对照组(P<0.05)。结论反复的夜间低氧可使炎性因子升高,降低抑炎因子水平。Objective To investigate the levels of the interleukin 10,NO and CRP in patients with obstructive sleep apnea-hypopnea syndrome.Methods thirty-five severe OSAHS male patients underwent uvulopalatopharyngoplasty were selected as OSAHS group and matched for age,BMI to twenty-five health persons as control group.Serum levels of IL-10,NO and CRP were measured by ELISA.Results The level of CRP was significantly higher than those in control but IL-10 and NO were significantly lower.Conclusion The levels of IL-10,CRP and NO might be related with hypoxemia occurred repeatedly during night.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 白细胞介素10 一氧化氮 C反应蛋白 

分 类 号：R766[医药卫生—耳鼻咽喉科]