海洛因成瘾者静息状态下脑功能连接研究  

The Differents in Brain Functional Connectivity Between Heroin Dependent Patients and Normal Contrals at Conscious Resting State

作　　者：王绪轶[1] 李宝娟[2] 周旭辉[3] 刘铁桥[1] 胡德文[2] 郝伟[1] 

机构地区：[1]中南大学湘雅二医院精神卫生研究所,湖南长沙410011 [2]国防科技大学机电工程与自动化学院,湖南长沙410011 [3]湖南省脑科医院

出　　处：《中国临床心理学杂志》2011年第1期7-9,共3页Chinese Journal of Clinical Psychology

基　　金：国家重点基础研究发展973计划(2009CB522000);国家自然科学基金(30971050);教育部博士点基金新教师项目(78720070533068)资助

摘　　要：目的:探讨海洛因成瘾者在静息状态下脑功能连接与正常对照的区别。方法:对16例海洛因成瘾者和16例匹配的正常对照进行静息状态下的脑功能扫描。选择杏仁核为种子区,比较两组之间脑功能连接的区别。结果:同正常对照相比,海洛因成瘾者杏仁核与左右扣带回、左右扣带回前部以及右侧Brodmann 24脑区功能连接下降。结论:这种功能连接的下降可能反映出海洛因成瘾者的杏仁核功能处于脱抑制状态,造成海洛因成瘾者犒赏、动机、记忆功能异常,从而参与了海洛因成瘾行为产生和维持。Objective：To study the differents in brain functional connectivity between heroin dependent patients and normal controls at conscious resting state.Methods：Using fMRI,we investigated the brain functional connecticity in 16 heroin-dependented patients and 16 matched normal controls.We selected the amaygdala as seed.Results：Compared with controls,the heroin addicts had significant（P〈0.005） decreased brain functional connectivity between amygdala and some brain regions,including bilateral cingulate gyrus,bilateral anterior cingulate and right brodmann area 24.Conclusion：This study shows that there are abnormal functional connectivity in heroin dependent patients.These functional deficiencies may be correlated with occurrence and maintenance of addiction behaviors.

关 键 词：脑功能连接 功能磁共振 静息状态 杏仁核 扣带回 

分 类 号：R395.4[哲学宗教—心理学]