抑郁症认知易感者杏仁核体积的研究  

A Study on Amygdala Volumes of Individuals with Cognitive Vulnerablity to Depression

作　　者：张小崔[1] 廖坚[2] 朱雪玲[1] 肖晶[1] 姚树桥[1] 

机构地区：[1]中南大学湘雅二医院医学心理研究所,湖南长沙410011 [2]中南大学湘雅三医院放射科,湖南长沙410013

出　　处：《中国临床心理学杂志》2011年第1期10-13,共4页Chinese Journal of Clinical Psychology

基　　金：国家自然科学基金资助项目(30670709)

摘　　要：目的:比较基于最弱连接理论确认的抑郁症认知易感者与首发重性抑郁症患者杏仁核体积的差异,探讨在抑郁症发生过程中杏仁核体积变化的特点。方法:应用磁共振成像(MRI)检测29例抑郁症认知易感者、27例未用药首发重性抑郁症患者及25例健康对照者的杏仁核体积。结果:三组被试的右侧杏仁核体积存在显著组间差异,F(2,78)=5.467,P<0.001,其中抑郁症认知易感者组杏仁核体积显著小于首发重性抑郁症组的,但与健康对照组两侧杏仁核体积均无显著差异;抑郁症认知易感者组左、右两侧杏仁核体积与其CSQ结果认知因子得分均呈正相关(r=0.371,P<0.05;r=0.399,P<0.05)。结论:基于最弱连接理论确认的抑郁症认知易感者杏仁核体积显著小于首发重性抑郁症患者杏仁核体积,但与健康对照组无显著差异;抑郁症认知易感者杏仁核体积与事件结果负性认知过程有一定关联。Objective：To study the amygdala volumes of individuals with cognitive vulnerability to depression based on the weakest link hypothesis and patients with first-episode of major depression,and explore the changes of amygdala volumes during the progress of depression.Methods：The amygdala volumes of 29 individuals with cognitive vulnerablity to depression,27 patients with first-episode of major depression and 25 age-and gender-matched healthy controls were gained by Magnetic Resonance Imaging（MRI）.Results：Individuals with cognitive vulnerablity to depression revealed smaller right amygdala volumes compared with patients with first-episode of major depression,but no significant difference with healthy controls.Amygdala volumes positively correlated with consequences cognitive scores of CSQ in individuals with cognitive vulnerability to depression（left：r=0.371,P〈0.05;right：r=0.399,P〈0.05）.Conclusion：Individuals with cognitive vulnerablity to depression reveal smaller right amygdala volumes compared with patients with first episode of major depression,but no significant difference with healthy controls.Amygdala volumes of individuals with cognitive vulnerability to depression may be related to the progress of negative cognition about the consequences of life events.

关 键 词：抑郁症 认知易感性 杏仁核 磁共振成像 

分 类 号：R395.4[哲学宗教—心理学]