正常人和精神分裂症患者脑灰质体积分析的性别效应  

Sex Effects on the Gray Matter Volume in Normal Subjects or Schizophrenic Patients

作　　者：李丽[1] 陶好娟[1] 刘海洪[2] 刘哲宁[1] 薛志敏[1] 

机构地区：[1]中南大学湘雅二医院精神卫生研究所,湖南长沙410011 [2]中南大学湘雅医院心理中心,湖南长沙410008

出　　处：《中国临床心理学杂志》2011年第1期14-17,共4页Chinese Journal of Clinical Psychology

摘　　要：目的:通过比较男性和女性正常人、男性和女性精神分裂症患者之间的脑灰质体积差异,探讨脑结构分析中的性别效应。方法:采集60例正常人(30例男性)和96例精神分裂症患者(48例男性)的高分辨率三维脑结构磁共振图像,运用基于体素的形态测量法(VBM)进行分析,获得每一个体的脑灰质体积图像。采用两样本t检验分别比较男性和女性正常人,男性和女性精神分裂症患者之间的脑灰质体积差异。结果:与女性正常人相比,男性正常人左侧的颞中回和额中回、右侧的边缘叶和颞中回的灰质体积较大(P<0.001),而左侧尾状核和右侧海马的灰质体积较小(P<0.001)。与女性精神分裂症患者相比,男性患者双侧的颞下回和海马、左侧的颞上回和颞中回的灰质体积较大(P<0.001),而未发现灰质体积较小的脑区。结论:性别效应是影响正常人或精神分裂症患者脑结构分析的重要因素。Objective：To explore the sex effects on brain structure.Methods：Normal subjects（n=60） and schizophrenic patients（n=96） were assigned into four groups：male（n=30） and female（n=30） normal subjects,male（n=48） and female（n=48） patients.Structural brain images were acquired for all subjects by magnetic resonance imaging machine,and the individual gray matter volume（GMV） images were obtained by the ＂unified segmentation＂ approach in voxel-based morphometry.The GMV difference between the male and female normal subjects and patients were examined by two-sample T-test,with age and total incranial volume introduced as covariants.Results：Compared with the female normal subjects,male normal subjects showed increased GMV in the left hemispheric middle temporal gyrus and middle frontal gyrus,right hemispheric limbic and middle temporal gyrus（P〈0.001）,while decreased GMV in the left caudate nucleus and right hippocampus（P〈0.001）.Compared with the female schizophrenic patients,male patients showed increased GMV in the bilateral inferior temporal gyrus and hippocampus,left hemispheric superior temporal gyrus and middle temporal gyrus（P〈0.001）,not finding decreased GMV in the whole brain.Conclusion：Sex effects play an important role in structural brain analysis,both in normal subjects and in schizophrenic patients.

关 键 词：精神分裂症 性别效应 灰质体积 基于体素的形态测量法 

分 类 号：R395.4[哲学宗教—心理学]