药物驱蜱对新疆出血热流行抑制作用的现场实验研究  

A field experimentation on the inhibitory effects of tick management with avermectin on the prevalence of Xinjiang hemorrhagic fever

作　　者：李冰[1] 木合塔[1] 王启果[1] 王信惠[1] 阿布力克木[1] 孟卫卫[1] 戴翔[1] 张渝疆[1] 

机构地区：[1]新疆维吾尔自治区疾病预防控制中心,乌鲁木齐830002

出　　处：《中国媒介生物学及控制杂志》2011年第1期5-7,共3页Chinese Journal of Vector Biology and Control

基　　金：国家自然科学基金(30860225;81060129);国家"十五"科技攻关项目(2003BA712A08-03)~~

摘　　要：目的探讨药物驱蜱对新疆出血热(XHF)在家畜中流行的抑制效果。方法采用药物驱蜱方式对塔里木盆地疫区内的羊群进行对比实验研究。结果实验组羔羊在服用驱蜱药物阿维菌素后,羔羊体外寄生蜱的染蜱率为55.0%,蜱指数为1.0,而未服用阿维菌素的对照组感染率为100%,蜱指数为11.2,实验组羔羊体外寄生蜱的感染率和蜱指数分别较对照组低45%和10.2;实验6个月后,实验组克里米亚-刚果出血热病毒(CCHFV)抗体阳性率为22.4%,显著低于对照组(45.9%),与实验组在实验前的CCHFV抗体阳性率(23.7%)基本一致。结论 XHF流行地区羔羊服用驱蜱药物阿维菌素可阻碍蜱类对羔羊的侵袭,抑制XHF在羔羊中的流行。Objective To evaluate the inhibitory effects of tick management with avermectin on the prevalence of Xinjiang hemorrhagic fever（XHF）, i.e. Crimean-Congo hemorrhagic fever（CCHFV）, in livestocks. Methods Comparative experimental study on the efficacy of tick management with avermectin was implemented in goats in the epidemic foci in the Tarim Basin. Results It was found that the tick infestation rate in the experimental group was 55.0% with a tick index of 1.0 after oral the administration of Avermectin, a tick management drug, for the goats and the rate and the index in the control group were 100% and 11.2, respectively, with the 2 parameters 45% and 10.2 respectively lower in the experimental group than in the control group. After six months’ experiment, the positive rate of antibody to XHF in the experimental group was 22.4%, consistent with the the rate before experiment（23.7%） but significantly lower than that in the control group（45.9%）. Conclusion Avermectin for goats in the epidemic foci of XHF contributes to the prevention of tick infestation and the prevalence of the epidemic in livestocks.

关 键 词：新疆出血热 药物驱蜱 抑制效果 

分 类 号：R373.3[医药卫生—病原生物学]