莪术醇饵剂对布氏田鼠的不育效果观察  

The anti-fertility effect of curcumol baits on Lasiopodomys brandti

作　　者：蒋永恩[1] 郭永旺[2] 施大钊[1] 杜桂林[3] 

机构地区：[1]中国农业大学鼠害防治实验室,北京100193 [2]全国农业技术推广中心 [3]全国畜牧总站

出　　处：《中国媒介生物学及控制杂志》2011年第1期22-25,共4页Chinese Journal of Vector Biology and Control

基　　金：国家"十一五"科技支撑课题(2006BAD16B04);国家自然科学基金(30800727)~~

摘　　要：目的研究莪术醇饵剂对布氏田鼠的不育效果。方法药饵浓度分别为0.1%、0.2%和0.4%,对照组饲喂药饵饵基;采用自由取食方式给药,连续饲喂3周后剖检,剖检时观测试鼠生殖器官形态并计算脏器系数,对雄鼠测定其精子品质。结果莪术醇对雌雄两性布氏田鼠均有抗生育作用;对雌鼠,0.2%、0.4%浓度组雌鼠卵巢发育异常,卵泡滞育;各剂量组试鼠子宫脏器系数升高、子宫水肿,水肿程度与给药浓度呈正相关;对雄鼠,给药试鼠精子活力、密度、存活率降低,精子畸形率上升,且畸形精子表现为顶体帽缺失;给药试鼠附睾脏器系数降低,且降低程度与给药浓度呈正相关;莪术醇药饵对雌雄布氏田鼠个体发育无影响。结论莪术醇对布氏田鼠有抗生育作用,但药物作用持续时间及作用是否可逆等问题需进一步研究。Objective To determine the anti-fertility effect of curcumol baits on Lasiopodomys brandti. Methods The experimental group was fed with baits of 3 doses, 0.1%, 0.2% and 0.4%, respectively, while the control group received nontoxic blanks. The voles freely consumed the baits for 3 consecutive weeks before gross examination, in which the morphology of genital organs was observed, and the organ coefficient calculated. The sperm quality was measured for male animals. Results Curcumol baits were effective anti-fertility agents against both male and female L. brandti. As for female voles, abnormal ovarian development was observed with impaired follicular maturation in the 0.2% and 0.4% dose groups; increased organ coefficient for the uterus was present in each dose group along with uterine edema, the extent of which was positively correlated with the dose administration. As for male animals, intoxicated individuals had lowered sperm motility, concentration and viability in addition to increased risk of sperm malformation, where the most common abnormality was acrosomal loss; their epididymal organ coefficient also declined to a degree positively correlated with the dose. Curcumol did not affect the individual development of either gender. Conclusion While curcumol baits had anti-fertility effects on L. brandti, the duration and recoverability of drug effect should be further studied.

关 键 词：莪术醇 布氏田鼠 不育效果 

分 类 号：S443[农业科学—农业昆虫与害虫防治] S481.9[农业科学—植物保护]