从糖尿病大鼠周围神经组织形态学变化论证“络损”病机学说  

Talk About the "Collaterals Loss Theory" Pathogenesis from Morphological Changes with Diabetic Rats Nerve Tissue

作　　者：张兰[1] 马帅[1] 

机构地区：[1]辽宁中医药大学附属医院,沈阳110032

出　　处：《光明中医》2011年第2期224-226,共3页GUANGMING JOURNAL OF CHINESE MEDICINE

基　　金：辽宁省高等学校优秀人才支持计划(No.2009R40)

摘　　要：目的观察正常组大鼠及模型组大鼠周围神经形态、血清MBP改变,从形态学角度论证"络损"病机学说。方法将大鼠设为正常组与模型组,模型组用链脲佐菌素(STZ)造模,6周后分别观察糖尿病大鼠周围神经形态、血清MBP改变。结果糖尿病大鼠在成模时血清MBP较正常组明显升高且存在以轴索和脱髓鞘改变为主要表现的神经组织自身损害。结论证明了"络损"病机学说中神经组织在形态和功能上与中医的"络脉"的类似性,DPN"络损"除微血管和微循环病变之外,尚存在神经组织自身损害。Objective To observe the normal rats and model rats,peripheral nerve sharp,serum MBP change,from the Angle of morphological expound and prove＂collaterals loss theory＂.Methods To divided normal rats with model group,and group with urea chain model group,STZ（with the） were observed,diabetic rats peripheral nerve sharp,serum MBP change.Results diabetic rats in ChengMo than normal controls when MBP serum and increased significantly in axonal demyelinated and change of nerve tissue itself.Conclusion the ＂proof＂in the theory of pathogenesis flashover loss in form and function of nerve tissue with Chinese medicine,analogue meridians ＂collaterals loss＂except ailability of microcirculation lesions,capillaries and existing neural tissue itself.

关 键 词：大鼠 糖尿病周围神经病变 周围神经组织形态学 络损 病机 中医实验医学 

分 类 号：R259[医药卫生—中西医结合]