毛冬青中三萜皂苷类化合物的分离(Ⅲ)  

Triterpene Saponins Isolated from Ilex pubescens (Ⅲ)

作　　者：张翠仙[1] 林朝展[1] 杨金燕[1] 熊天琴[1] 邓洁薇[1] 韦瑀龙[1] 赵钟祥[1] 祝晨蔯[1] 

机构地区：[1]广州中医药大学中药学院,广东广州510006

出　　处：《中山大学学报（自然科学版）》2011年第1期70-74,共5页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：高等学校博士学科点专项科研基金联合资助项目(20094425110008);广东省科技厅国际合作资助项目(2008A050200005);广东省中医药管理局基金资助项目(2007336);广州中医药大学创新基金资助项目(2007C016;09CX015);国家中医药管理局重大科技专项(中药质量研究专论)资助项目(国中医药科2001ZDZX005)

摘　　要：药理活性研究表明,毛冬青总皂苷不仅具有明显降低血浆粘度的作用,而且还能明显抑制兔离体动脉条的收缩。继续对其总皂苷的化学成分进行研究,从其正丁醇萃取部位分离得到5个三萜皂苷类化合物,经理化性质及波谱方法鉴定为:mussaendoside R(1)、ziyu-glycoside I(2)、Lucyoside H(3)、ilexoside A(4)、il-exoside O(5)。其中1、2、3为首次从该植物中分离得到。Traditional chinese medicine of Ilex pubescens（Mao-Dong-Qing） is commonly used to treat the cardiovascular diseases in South China.The preliminary bioassays showed that the total saponins isolated from Ilex pubescens exhibited significant potent degrading the plasma viscosity in rats.Meanwhile,our recent works indicated that the n-BuOH soluble fractions of ethanol extract（70%） from the root of the same species obviously inhibited the contraction（60 μg/mL） of rabbit thoracic aorta induced by norpinephrine in vitro.As a continuation of bioactive constituent from the n-BuOH of Ilex pubescens,five triterpene saponins were isolated.Their structures were elucidated by chemical,physical methods and spectroscopic analysis methods.As a result,they were identified as mussaendoside R（1）,ziyu-glycoide I（2）,Lucyoside H（3）,ilexoside A（4）,ilexoside O（5）,excepescially.Compounds 1,2 and 3 were firstly obtained from Ilex pubescens.

关 键 词：毛冬青 三萜皂苷类化合物 结构研究 

分 类 号：O629.7[理学—有机化学]